Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients
Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients
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DOI：
10.1016/j.vaccine.2009.03.050
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发表时间：
2009-06-02
期刊：
影响因子：
5.5
通讯作者：
Autran, Brigitte
中科院分区：
文献类型：
--
作者：
Puissant-Lubrano, Benedicte;Combadiere, Behazine;Autran, Brigitte
The role of antigen exposure and of CD4 cell deficiency in the long-term persistence of immune memory to childhood vaccines remains uncertain, particularly during HIV infection. We analyzed in vaccinated ART-treated HlV(+) patients with undetectable plasma HIV and CD4 cells >250/mm(3) the persistence of two memory cell pools: effector IFN gamma-producing and proliferative central memory T cells against two vaccines: (i) vaccinia against the eradicated smallpox virus, and (ii) BCG against Mtb, a persistent pathogen. None of the HIV+ patients had IFN gamma-effector cells against VV while the one patient with BCG-specific effector T cells had a recent history of tuberculosis. Proliferative responses were detectable but showed significantly lower frequency and intensity of W-specific than tuberculin-specific responses, independently of the CD4 nadir. Thus, differential patterns of persistence or recovery of T cell memory pools against childhood vaccines are observed in treated HIV infection that are governed by antigen exposure. (C) 2009 Elsevier Ltd. All rights reserved.
