Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells
Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells
复制标题
DOI：
10.1016/j.ijgo.2016.06.026
复制
发表时间：
2016-12-01
影响因子：
3.8
通讯作者：
El-Khayat, Waleed
中科院分区：
文献类型：
--
作者：
Dakhly, Dina M. R.;Bayoumi, Yomna A.;El-Khayat, Waleed
目的：探讨脂质内补充对体外受精/胞浆内单精子注射后自然杀伤细胞活性升高的复发性自然流产（RSA）妇女的治疗效果。方法：2013年2月10日至2015年4月30日，在埃及某中心进行双盲随机对照研究。患有不明原因继发性不孕症、RSA和自然杀手细胞水平升高（>12%）的妇女被纳入研究，并随机分配在取卵当天接受脂质内输注（2ml在250ml生理盐水中以20%稀释）或生理盐水（250ml）输注，使用随机数和密封信封。病人和主治医生被分组分配。在妊娠试验呈阳性的1周内重复注射，然后每2周注射一次，直到妊娠早期结束。主要结局为胚胎移植后14天化学妊娠。分析是按意向治疗。结果：总共有296名女性入组。脂内组144例中84例（58.3%）发生化学妊娠，对照组152例中76例（50.0%）发生化学妊娠（P = 0.129）。结论：脂质内补充不增加化学妊娠的发生率。然而，与持续妊娠和活产有关的发现应进一步调查。(C) 2016年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To investigate the efficacy of intralipid supplementation in women with recurrent spontaneous abortion (RSA) and elevated natural killer cell activity undergoing in vitro fertilization/intracytoplasmic sperm injection. Methods: Between February 10, 2013, and April 30, 2015, a double-blind randomized controlled study was conducted at a center in Egypt. Women with unexplained secondary infertility, RSA, and elevated levels of natural killer cells (>12%) were enrolled and randomly assigned to receive intralipid (2 mL diluted at 20% in 250 mL saline) or saline (250 mL) infusion on the day of oocyte retrieval using random numbers and sealed envelopes. Patients and attending physicians were masked to group assignment. The infusions were repeated within 1 week of a positive pregnancy test and then every 2 weeks until the end of the first trimester. The primary outcome was chemical pregnancy 14 days after embryo transfer. Analyses were by intention-to treat. Results: Overall, 296 women were enrolled. Chemical pregnancy was recorded for 84 (58.3%) of 144 women in the intralipid group and 76 (50.0%) of 152 in the control group (P = 0.129). Conclusion: Intralipid supplementation did not increase frequency of chemical pregnancy. However, findings related to ongoing pregnancy and live birth should be investigated further. (C) 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.