Agminated flexural melanocytic nevus associated with Langerhans cell histiocytosis.
Agminated flexural melanocytic nevus associated with Langerhans cell histiocytosis.
复制标题
与朗格汉斯细胞组织细胞增多症相关的弯曲黑素细胞痣。
DOI：
10.1111/1346-8138.15391
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Shimizu T.
中科院分区：
文献类型：
--
作者：
Makino T;Matsui Y;Torai R;Mizawa M;Shimizu T.
图1. (a)临床检查发现腹股沟区有色素斑。(b)皮肤镜图像显示球形图案。(c)皮肤病变的组织学检查显示真皮表皮连接处的黑色素细胞巢（苏木精-伊红[HE]，原始放大倍数9200）。(d)聚集性弯曲黑素细胞痣中Melan-A（绿色）和langerin（红色）的双重染色。用40，6-联脒-20-苯基吲哚二盐酸盐染色的DNA显示为蓝色。虚线表示真皮表皮连接（9200）。(e)电脑断层扫描显示颅骨骨质溶解。(f)颅骨的组织学检查显示许多朗格汉斯细胞（HE，9100）。(g)免疫组化显示langerin阳性（9200）。
Figure 1.(a) Clinical examination revealed pigmented macules in the inguinal region.(b) Dermoscopic image showing a globular pattern.(c) Histological examination of the skin lesion showing melanocytic nests at the dermoepidermal junction (hematoxylin–eosin [HE], original magnification 9200).(d) Double staining of Melan-A (green) and langerin (red) in an agminated flexural melanocytic nevus. DNA staining by 40, 6-diamidine-20-phenylindole dihydrochloride appears in blue. The dotted line indicates the dermoepidermal junction (9200).(e) Computed tomography showing osteolysis in the skull.(f) Histological examination of the skull revealed many Langerhans cells (HE, 9100).(g) Immunohistochemistry revealed langerin positively (9200).