Seasonal coronavirus protective immunity is short-lasting
Seasonal coronavirus protective immunity is short-lasting
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DOI：
10.1038/s41591-020-1083-1
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发表时间：
2020-09-14
期刊：
影响因子：
82.9
通讯作者：
van der Hoek, Lia
中科院分区：
文献类型：
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作者：
Edridge, Arthur W. D.;Kaczorowska, Joanna;van der Hoek, Lia
在当前的2019冠状病毒病（COVID-19）大流行中，一个关键的未解决问题是获得性免疫的持续时间。从四种季节性人类冠状病毒感染中获得的启示可能会揭示适用于所有人类冠状病毒的共同特征。我们对健康个体进行了超过35年的监测，并确定在感染后12个月经常发生相同季节性冠状病毒的再感染。对严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）免疫的持久性尚不清楚。人类季节性冠状病毒感染的经验表明，初次感染后12个月内可发生再次感染，并伴有病毒特异性抗体水平的变化。
A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.The durability of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. Lessons from seasonal coronavirus infections in humans show that reinfections can occur within 12 months of initial infection, coupled with changes in levels of virus-specific antibodies.