BETA-ENDORPHIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF MONKEYS ARE INFLUENCED BY GROOMING RELATIONSHIPS
BETA-ENDORPHIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF MONKEYS ARE INFLUENCED BY GROOMING RELATIONSHIPS
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DOI：
10.1016/0306-4530(89)90065-6
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发表时间：
1989-01-01
影响因子：
3.7
通讯作者：
TUITE, B
中科院分区：
文献类型：
--
作者：
KEVERNE, EB;MARTENSZ, ND;TUITE, B
社会关系与许多哺乳动物的行为密不可分。灵长类动物是不寻常的，因为它们的社会关系是广泛的群体，其中往往包含许多生殖活跃的男性和女性。已经提出了几个假说来解释灵长类动物社会性的最终原因。虽然注意力集中在梳理作为影响社会关系的近因，这种行为的神经基础尚未在猴子中进行调查。这份报告展示了猴子在梳理毛发时大脑阿片系统的变化。阿片类药物本身与梳理行为有反馈相互作用，如阿片激动剂和拮抗剂给药所示。阿片受体阻滞剂增加的动机被groomed.These数据支持的观点，大脑阿片类物质在介导社会依恋中发挥着重要作用，并可能提供灵长类动物的社会性进化的神经基础。
Social relationships are intergral to the behaviour of many mammalian species. Primates are unusual in that their social relationships are extensive within groups, which often contain many reproductively active males and females. Several hypotheses have been forwarded to explain the ultimate causation of primate sociality. While attention has focused on grooming as a proximate factor influencing social relationships, the neural basis of such behaviour has not been investigated in monkeys. This report presents changes in the brain''s opioid system contingent on grooming in monkeys. Opiates themselves have a feedback interaction with grooming behaviour, as revealed from the administration of opiate agonists and antagonists. Opiate receptor blockade increases the motivation to be groomed, while morphine administration decreases it. These data support the view that brain opioids play an important role in mediating social attachment and may provide the neural basis on which primate sociality has evolved.