Double Dissociation of Auditory Attention Span and Visual Attention in Long-Term Survivors of Childhood Cerebellar Tumor: A Deterministic Tractography Study of the Cerebellar-Frontal and the Superior Longitudinal Fasciculus Pathways
Double Dissociation of Auditory Attention Span and Visual Attention in Long-Term Survivors of Childhood Cerebellar Tumor: A Deterministic Tractography Study of the Cerebellar-Frontal and the Superior Longitudinal Fasciculus Pathways
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DOI：
10.1017/s1355617720000417
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发表时间：
2020-11-01
影响因子：
2.6
通讯作者：
Crosson, Bruce
中科院分区：
文献类型：
--
作者：
Ailion, Alyssa S.;King, Tricia Z.;Crosson, Bruce
目的：研究了右小脑-左额叶（RC-LF）白色质完整性（RC-LF）与工作记忆的关系。然而，先前的研究采用了工作记忆的测量方法，包括处理速度和注意力。本研究旨在探讨RC-LF加工与加工速度、注意和工作记忆的关系，以阐明RC-LF加工与特定认知功能的关系。右上级纵束II（SLF II）的神经和视觉注意力被列为阴性对照道和任务，以证明一个双dissociation.Methods：成年幸存者的儿童脑肿瘤[n = 29，年龄：M = 22岁（SD = 5），45%的女性]和人口统计学匹配的对照组被招募（n = 29）。听觉注意广度、工作记忆和视觉注意力测试作为认知测量。参与者完成了3-T MRI弥散加权成像扫描。分数各向异性（FA）和径向扩散率（RD）作为非线性测量。RC-LF重复与听觉注意力相关（FA：r = .42，p = .03; RD：r = -.50，p = .01），与视觉注意力无关（FA：r = -.11，p = .59; RD：r = -.11，p = .57）。SLF II FA评分与视觉注意力相关（FA：r = .44，p = .02; RD：r = -.17，p = .40），与听觉注意无关（FA：r = .24，p = .22; RD：r = -.10，p = .62）。结果表明，RC-LF重复与听觉注意广度相关，而不是工作记忆本身，并提供了基于相关性的特异性证据。双重解离
Objective:Right cerebellar-left frontal (RC-LF) white matter integrity (WMI) has been associated with working memory. However, prior studies have employed measures of working memory that include processing speed and attention. We examined the relationships between the RC-LF WMI and processing speed, attention, and working memory to clarify the relationship of RC-LF WMI with a specific cognitive function. Right superior longitudinal fasciculus II (SLF II) WMI and visual attention were included as a negative control tract and task to demonstrate a double dissociation.Methods:Adult survivors of childhood brain tumors [n = 29, age: M = 22 years (SD = 5), 45% female] and demographically matched controls were recruited (n = 29). Tests of auditory attention span, working memory, and visual attention served as cognitive measures. Participants completed a 3-T MRI diffusion-weighted imaging scan. Fractional anisotropy (FA) and radial diffusivity (RD) served as WMI measures. Partial correlations between WMI and cognitive scores included controlling for type of treatment.Results:A correlational double dissociation was found. RC-LF WMI was associated with auditory attention (FA: r = .42, p = .03; RD: r = -.50, p = .01) and was not associated with visual attention (FA: r = -.11, p = .59; RD: r = -.11, p = .57). SLF II FA WMI was associated with visual attention (FA: r = .44, p = .02; RD: r = -.17, p = .40) and was not associated with auditory attention (FA: r = .24, p = .22; RD: r = -.10, p = .62).Conclusions:The results show that RC-LF WMI is associated with auditory attention span rather than working memory per se and provides evidence for a specificity based on the correlational double dissociation.