Statins Decrease Oxidative Stress and ICD Therapies.
Statins Decrease Oxidative Stress and ICD Therapies.
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DOI：
10.4061/2010/253803
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发表时间：
2010
影响因子：
2.1
通讯作者：
Dudley SC
中科院分区：
文献类型：
--
作者：
Bloom HL;Shukrullah I;Veledar E;Gutmann R;London B;Dudley SC
最近的研究表明，他汀类药物可减少内部心律转复除颤器（ICD）患者的室性心律失常。其机制尚不清楚，但有证据表明炎症和氧化状态的增加与心律失常的增加有关。我们假设他汀类药物的使用减少了氧化。方法.对304例植入ICD的受试者进行了室性心律失常调查。分析血液中活性氧衍生物（DROMs）和白细胞介素-6（IL-6）。结果受试者包括252名（83%）男性，58%接受他汀类药物治疗，20%患有室性心律失常。平均年龄63岁，射血分数（EF）20%。ICD植入持续时间为29 ± 27个月。他汀类药物的使用与较低的ICD事件相关（r = 0.12，P = 0.02）。接受他汀类药物治疗的受试者hsCRP（5.2 vs 6.3; P = .05）和DROM水平（373 vs 397; P = .03）较低。其他因素，包括IL-6和EF在他汀类药物和非他汀类药物使用之间没有差异，β受体阻滞剂或抗肿瘤药物的使用也没有差异。多因素交叉相关分析显示，DROMs、他汀类药物、IL-6和EF与ICD事件密切相关。多元回归分析显示DROMs是主要的预测因子。结论ICD事件发生率与DROM（一种脂质过氧化物的测量方法）相关。他汀类药物的使用与DROM减少和ICD事件减少相关，表明他汀类药物通过减少氧化发挥作用。
Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD) patients. The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias. We hypothesized that statin use decreases oxidation. Methods. 304 subjects with ICDs were surveyed for ventricular arrhythmia. Blood was analyzed for derivatives of reactive oxygen species (DROMs) and interleukin-6 (IL-6). Results. Subjects included 252 (83%) men, 58% on statins, 20% had ventricular arrhythmias. Average age was 63 years and ejection fraction (EF) 20%. ICD implant duration was 29 ± 27 months. Use of statins correlated with lower ICD events (r = 0.12, P = .02). Subjects on statins had lower hsCRP (5.2 versus 6.3; P = .05) and DROM levels (373 versus 397; P = .03). Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use. Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events. Multivariate regression shows DROMs to be the dominant predictor. Conclusion. ICD event rate correlates with DROMs, a measure of lipid peroxides. Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.