The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.
The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.
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DOI：
10.1002/oby.21189
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Scheer FA
中科院分区：
文献类型：
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作者：
Morris CJ;Garcia JI;Myers S;Yang JN;Trienekens N;Scheer FA
饮食诱导的产热（DIT）在晚上和晚上比早上低。这可能有助于解释为什么吃饭时间会影响体重调节，以及为什么轮班工作是肥胖的危险因素。内源性昼夜节律系统（独立于行为周期）和昼夜节律失调对DIT的单独影响尚不清楚。13名健康成年人进行了一项随机交叉研究，包括两次为期8天的实验室访视：三个基线日，然后重复模拟夜班，包括12小时倒置行为周期（昼夜节律失调）或重复模拟日间轮班（昼夜节律调整）。在两种方案中，在上午8点和下午8点给予相同的膳食后，确定DIT长达114分钟（下文称为“早期DIT”）。在基线期间，晚上的早期DIT比早上低44%。这主要是由昼夜节律的影响，而不是任何行为周期的影响解释;早期的DIT是50%，低于生物晚上比生物上午，独立的行为周期的影响。昼夜节律失调对早期DIT没有总体影响。昼夜节律系统在DIT早期的早晚差异中起主导作用，并可能有助于进食时间对体重调节的影响。
Diet-induced thermogenesis (DIT) is lower in evening and at night than in the morning. This may help explain why meal-timing affects body weight regulation and why shift work is a risk factor for obesity. The separate effects of the endogenous circadian system—independent of behavioral cycles—and of circadian misalignment on DIT are unknown. Thirteen healthy adults undertook a randomized, crossover study with two 8-day laboratory visits: three baseline days followed either by repeated simulated night shifts including 12-h inverted behavioral cycles (circadian misalignment) or by recurring simulated day shifts (circadian alignment). DIT was determined for up to 114 min (hereafter referred to as “early DIT”) following identical meals given at 8AM and 8PM in both protocols. During baseline days, early DIT was 44% lower in the evening than morning. This was primarily explained by a circadian influence rather than any behavioral cycle effect; early DIT was 50% lower in the biological evening than biological morning, independent of behavioral cycle influences. Circadian misalignment had no overall effect on early DIT. The circadian system plays a dominating role in the morning/evening difference in early DIT and may contribute to the effects of meal-timing on body weight regulation.