Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocytes.
Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocytes.
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人类精子的运动特征与其穿透宫颈粘液和无带仓鼠卵母细胞的能力之间的关系。
DOI：
10.1530/jrf.0.0730441
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
D. Richardson
中科院分区：
文献类型：
--
作者：
R. Aitken;M. Sutton;P. Warner;D. Richardson
在一组正常精子捐献者中，金黄地鼠卵母细胞穿透率为0-100%，多元回归分析表明，受精潜力的变化只有20%可以用体外孵化后精子运动特征的差异来解释。当考虑到精子在精液中的运动特征时，这一数字降至6.8%，这是由于精液和孵化后的精子群体表现出的运动模式的显着差异所致。人类精子在精液中的运动特性与其穿透宫颈粘液的能力之间的关系更为密切。当考虑到活动精子密度的差异时，宫颈粘液穿透的变化的76%可以通过与精子运动的某些方面的线性相关来解释(多重R=0.874)。在所测量的精子活力的各种属性中(直线前进速度、旋转频率、精子头部位移幅度、%滚动和%偏航)，未能表现出足够的精子头部横向位移幅度一直被发现是决定精子-宫颈粘液相互作用成功的最重要因素(R2=0.53)。
In a group of normospermic donors exhibiting hamster oocyte penetration scores of 0-100%, multiple regression analysis indicated that only 20% of the variation in fertilizing potential could be explained by differences in the movement characteristics of the spermatozoa following incubation in vitro. When the movement characteristics of the spermatozoa in semen were considered this figure was reduced to 6.8% as a result of significant differences in the motility patterns exhibited by the seminal and post-incubation sperm populations. A much closer relationship was observed between the movement characteristics of human spermatozoa in semen and their ability to penetrate cervical mucus. When differences in motile sperm densities were taken into account, 76% of the variation in cervical mucus penetration could be accounted for by the existence of linear correlations with certain aspects of sperm movement (multiple R = 0.874). Of the various attributes of sperm motility measured (linear velocity of progression, frequency of rotation, amplitude of sperm head displacement, % rolling and % yawing), a failure to exhibit an adequate amplitude of lateral sperm head displacement was consistently found to be the most significant factor determining the success of sperm-cervical mucus interaction (R2 = 0.53).