Ocular coherence tomography image data of the retinal laminar structure in a mouse model of oxygen-induced retinopathy.
Ocular coherence tomography image data of the retinal laminar structure in a mouse model of oxygen-induced retinopathy.
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DOI：
10.1016/j.dib.2017.09.075
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发表时间：
2017-12
期刊：
影响因子：
1.2
通讯作者：
Mitton KP
中科院分区：
文献类型：
--
作者：
Dailey WA;Drenser KA;Wong SC;Cheng M;Vercellone J;Roumayah KK;Feeney EV;Deshpande M;Guzman AE;Trese M;Mitton KP
本文中呈现的数据与题为“Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia”（Dailey et al.，这篇文章描述了用人Norrin蛋白（一种非典型Wnt蛋白）治疗，以改善氧诱导视网膜病变（OIR）小鼠模型中视网膜神经节细胞的存活率。该研究利用光学相干断层扫描（OCT）在体内以高分辨率可视化视网膜层，并量化神经纤维层厚度的变化。由于在传统组织学的组织处理过程中关于潜在伪影的不确定性，该模型中其他视网膜层的层状结构在体内的组织尚不清楚。这里提供的OCT图像数据向研究人员展示了在这种流行的小鼠OIR模型中存在于体内的视网膜层状结构特征。传统的H&E染色的视网膜组织切片也提供在这里进行比较。
The data presented in this article are related to the research paper entitled “Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia” (Dailey et al., 2017) This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR). That study utilized Optical coherence tomography (OCT) to visualize retinal layers at high resolution in vivo, and to quantify changes to nerve fiber layer thickness. Organization of the laminar structure of other retinal layers in this model in vivo, were not known because of uncertainties regarding potential artifacts during the processing of tissue for traditional histology. The OCT image data provided here shows researchers the retinal laminar structural features that exist in vivo in this popular mouse OIR model. Traditional H&E stained retinal tissue sections are also provided here for comparison.