ENVIRONMENTALLY-INDUCED CHANGES IN BRAINS OF ELDERLY RATS
ENVIRONMENTALLY-INDUCED CHANGES IN BRAINS OF ELDERLY RATS
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DOI：
10.1038/243516a0
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发表时间：
1973-01-01
期刊：
影响因子：
64.8
通讯作者：
HORSFALL, CR
中科院分区：
文献类型：
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作者：
CUMMINS, RA;WALSH, RN;HORSFALL, CR
与没有以这种方式暴露的动物相比，暴露在环境刺激下的动物在大脑结构和生化方面出现了显著的差异1-4。影响这些变化幅度的因素是饲养的持续时间和动物在环境分离时的年龄。大多数研究都集中在幼年动物身上，因为在这个阶段，大脑被认为更具可塑性。因此，对诱导变化的时间分析通常局限于动物生命早期相当短的环境暴露时间。Rosenzweiget等人提出，在不同于断奶饲养的大鼠中，诱导的脑重量差异在分离的前30天达到最大，之后它们会减小。但这种双相反应的证据是基于相对较短的不同饲养周期(15-160天)。
ANIMALS that have been exposed to environmental stimulation develop marked differences in brain structure and biochemistry when compared with animals that have not been exposed in this way1–4. Factors influencing the magnitude of these changes are the duration of rearing and the age of the animals when the environmental separation takes place. Most studies have focused on young animals because the brain is thought to be more plastic at this stage. As a result, temporal analyses of the induced changes have usually been limited to fairly short periods of environmental exposure early in the animal's life. Rosenzweiget al.3have suggested that, in rats differentially reared from weaning, the induced differences in brain weight reach a maximum during the first 30 d of separation, after which they decrease. But the evidence for this biphasic response has been based on relatively short periods of differential rearing (15–160 d).