Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women
Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women
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DOI：
10.1016/j.exger.2019.05.013
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发表时间：
2019-09-01
影响因子：
3.9
通讯作者：
Sanchez-Arenas, Rosalinda
中科院分区：
文献类型：
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作者：
Basurto, Lourdes;Gregory, Michael A.;Sanchez-Arenas, Rosalinda
背景：动脉粥样硬化是心血管疾病（CVD）的主要危险因素。促炎生化因子可影响血管健康; CVD患者的单核细胞趋化蛋白-1（MCP-1）升高，而成纤维细胞生长因子-21（FGF-21）直接作用于心脏组织以减少梗死损伤。然而，MCP-1、FGF-21的血浆浓度与亚临床CVD指数之间的关系仍然不明确。颈动脉内膜中层厚度（cIMT）]。方法：对140例无CVD病史的女性进行横断面分析。收集人体测量数据，通过酶联免疫吸附测定法测定血清MCP-1和FGF-21浓度，并定量（B型超声）cIMT。MCP-1、FGF-21与亚临床动脉粥样硬化（即，结果：MCP-1、FGF-21与部分肥胖指标相关，而与部分肥胖指标无关。在组间中位数比较中，亚临床动脉粥样硬化显示较高的MCP-血清浓度和较低的FGF-21血清浓度。在绝经后妇女中，MCP-1（p = 0.001）和FGF-21（p = 0.010）存在显著差异。在患有亚临床动脉粥样硬化的绝经后妇女中，MCP-1（p = 0.001）和FGF-21（p = 0.037）之间的多元逻辑回归分析显示与cIMT相关，沿着年龄。cIMT）。进一步的努力集中在表征早期CVD病理学的新的血液传播标志物之间的关系是必要的，应该继续进行。
Background: Atherosclerosis is a primary risk factor for cardiovascular disease (CVD). Proinflammatory biochemical factors can influence vascular health; monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with CVD while fibroblast growth factor-21 (FGF-21) acts directly on cardiac tissue to reduce infarction damage. However, the relationship between plasma concentrations of MCP-1, FGF-21 and subclinical CVD indices remains equivocal.Aim: To determine the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD. Methods: A cross-sectional analysis of 140 women without history of CVD was performed. Anthropometrics were collected, serum concentrations of MCP-1 and FGF-21 were determined by enzyme-linked immunosorbent assay, and cIMT was quantified (B-mode ultrasonography). The correlations between MCP-1, FGF-21 and the presence of clinical and laboratory of subclinical atherosclerosis (i.e., cIMT >= 0.70 mm), comparison intergroup and odd ratio with multiple logistic regression were analyzed.Results: MCP-1, but not FGF-21 correlated with some obesity indicators. In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-land lower serum concentrations of FGF-21. In postmenopausal women, there were significant differences MCP-1 (p = 0.001), and FGF-21 (p = 0.010). Multiple logistic regression analysis in postmenopausal women with subclinical atherosclerosis, between MCP-1 (p = 0.001) and FGF-21 (p = 0.037) showed association with cIMT, along with age.Conclusions: MCP-1 and FGF-21 levels are associated with subclinical atherosclerosis disease severity (i.e., cIMT) in postmenopausal women without CVD. Further efforts focused on characterizing the relationship between novel blood-borne markers of early CVD pathology are warranted and should be pursued.