Screening of a branched peptide library with HIV-1 TAR RNA
Screening of a branched peptide library with HIV-1 TAR RNA
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DOI：
10.1039/b904304g
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Santos, Webster L.
中科院分区：
文献类型：
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作者：
Bryson, David I.;Zhang, Wenyu;Santos, Webster L.
认识到RNA不仅仅是从遗传密码到全功能蛋白质的信息传递的中间体，这使它处于化学研究的前沿。RNA是重要的，因为它在调节转录、翻译、剪接、复制和催化中起着至关重要的作用。因此，能够与RNA结合并控制其功能的分子有可能成为生物学和医学中的强大工具。在此，我们报告了使用4096个分支肽的文库的珠上筛选发现HIV-1 TAR RNA选择性配体。
The recognition that RNA is more than just an intermediate in the information transfer from genetic code to fully functional protein has placed it at the forefront of chemical research. RNA is important because of its vital role in regulating transcription, translation, splicing, replication and catalysis. Consequently, molecules that can bind to RNA and control its function have potential as powerful tools in biology and medicine. Herein, we report the discovery of HIV-1 TAR RNA-selective ligands using an on-bead screening of a library of 4096 branched peptides.