Relationship between MRI-Measured Bone Marrow Adipose Tissue and Hip and Spine Bone Mineral Density in African-American and Caucasian Participants: The CARDIA Study
Relationship between MRI-Measured Bone Marrow Adipose Tissue and Hip and Spine Bone Mineral Density in African-American and Caucasian Participants: The CARDIA Study
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DOI：
10.1210/jc.2011-2605
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Grunfeld, Carl
中科院分区：
文献类型：
--
作者：
Shen, Wei;Scherzer, Rebecca;Grunfeld, Carl
背景：越来越多的研究表明，骨髓脂肪组织(BMAT)可能在骨质疏松的发病机制中发挥作用。我们之前对高加索女性的研究表明，BMAT与全身骨密度(BMD)呈负相关。目前尚不清楚内脏脂肪组织(VAT)、皮下脂肪组织(SAT)和骨骼肌对BMAT和BMD之间的关系是否有影响。目的：在目前的研究中，我们在基于人群的青年冠状动脉风险发展(CARDIA)样本中调查了骨盆、髋部和腰椎BMAT与髋部和腰椎骨密度的关系，并调整了全身磁共振成像(MRI)测量的VAT、SAT和骨骼肌。设计：对210名健康的非裔美国人和高加索人(38-52岁)进行了T1加权磁共振成像。结果：骨盆、髋部和腰椎骨密度与髋部和腰椎骨密度呈负相关(r=-0.399~-0.550，P<；0.001)。在调整了人口统计学、体重、骨骼肌、SAT、VAT、总脂肪组织(TAT)、绝经状态、生活方式因素和炎症标志物后，BMAT和BMD之间的负相关性仍然很强(标准化回归系数=-0)。296%至-0.549，标准普尔0.001)。在身体成分测量中，校正BMAT后，骨骼肌与BMD的相关性最强(标准化回归系数=0.268-0.614，P<；0.05)，体重、SAT、VAT或总脂肪组织对BMD的贡献很小。结论：在这一中年人群中，MRI测量的BMAT与髋部和腰椎BMD之间存在负相关，与人口统计学和身体组成无关。这些观察结果支持了越来越多的证据表明BMAT与低骨密度有关。(临床内分泌代谢酶97：1337-1346,2012)
Context: An increasing number of studies suggest that bone marrow adipose tissue (BMAT) might play a role in the pathogenesis of osteoporosis. Our previous study of Caucasian women demonstrated that there is an inverse relationship between BMAT and whole-body bone mineral density (BMD). It is unknown whether visceral adipose tissue (VAT), sc adipose tissue (SAT), and skeletal muscle had an effect on the relationship between BMAT and BMD.Objective: In the present study we investigated the relationship between pelvic, hip, and lumbar spine BMAT with hip and lumbar spine BMD in the population-based Coronary Artery Risk Development in Young Adults (CARDIA) sample with adjustment for whole-body magnetic resonance imaging (MRI)-measured VAT, SAT, and skeletal muscle.Design: T1-weighted MRI was acquired for 210 healthy African-American and Caucasian men and women (age 38-52 yr). Hip and lumbar spine BMD were measured by dual-energy x-ray absorptiometry.Results: Pelvic, hip, and lumbar spine BMAT had negative correlations with hip and lumbar spine BMD(r = -0.399 to -0.550, P < 0.001). The inverse associations between BMAT and BMD remained strong after adjusting for demographics, weight, skeletal muscle, SAT, VAT, total adipose tissue (TAT), menopausal status, lifestyle factors, and inflammatory markers (standardized regression coefficients = -0. 296 to -0.549, P < 0.001). Among body composition measures, skeletal muscle was the strongest correlate of BMD after adjusting for BMAT (standardized regression coefficients = 0.268-0.614, P < 0.05), with little additional contribution from weight, SAT, VAT, or total adipose tissue.Conclusion: In this middle-aged population, a negative relationship existed between MRI-measured BMAT and hip and lumbar spine BMD independent of demographics and body composition. These observations support the growing evidence linking BMAT with low bone density. (J Clin Endocrinol Metab 97: 1337-1346, 2012)