High-precision microfluidic pressure control through modulation of dual fluidic resistances
High-precision microfluidic pressure control through modulation of dual fluidic resistances
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DOI：
10.1007/s40435-017-0378-7
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发表时间：
2018-09
影响因子：
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通讯作者：
Michael J. Toth;T. Kawahara;YongTae Kim
中科院分区：
文献类型：
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作者：
Michael J. Toth;T. Kawahara;YongTae Kim
提出了一种对微流控装置入口压力进行长期、高速、高精度(稳态误差小于0.5%)控制的双流控电阻调制方法。这是通过在加压储液器和微流控装置之间的流体网络中独立控制双可变电阻来实现的。通过实验比较我们的新模型和以前的方法，我们展示了双电阻调制系统的优越特性。我们证明了控制系统的性能，并解决了长期稳定性和鲁棒性问题。该系统可用于各种需要高精度、高速和长期控制微流体流的应用，包括化学合成、细胞分选、能量收集光流控、微生物燃料电池以及细胞或组织水平的多尺度生物研究。
This work presents an approach to the modulation of dual fluidic resistances for long-term, high-speed, and high precision (less than 0.5% steady-state error) control of the inlet pressure of a microfluidic device. This is accomplished through independent controls of dual variable resistances in a fluid network between a pressurized reservoir and a microfluidic device. We show the superior characteristics of the system with dual resistance modulation by experimentally comparing our new model with our previous approach. We demonstrate the performance of the controlled system and address the long-term stability and robustness. This system can be utilized in a variety of applications that require high-precision, high-speed, and long-term controls of microfluidic flows, including chemical synthesis, cell sorting, energy harvesting optofluidics, microbial fuel cells, and multiscale biological investigation of cellular or tissue level.