Frontispiece: A Simple Iridicycle Catalyst for Efficient Transfer Hydrogenation of N-Heterocycles in Water
Frontispiece: A Simple Iridicycle Catalyst for Efficient Transfer Hydrogenation of N-Heterocycles in Water
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卷首文章：一种简单的铱环催化剂，用于水中氮杂环的高效转移氢化
DOI：
10.1002/chem.201581462
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Talwar D
中科院分区：
文献类型：
--
作者：
Talwar D
环化的铱络合物显示出在温和条件下在HCO 2 H/HCO 2 Na的水溶液中催化各种氮杂环的转移氢化，所述氮杂环包括但不限于喹啉、异喹啉、吲哚和吡啶鎓盐。该催化剂显示出优异的官能团相容性和高转换数（高达7500），催化剂负载量低至0.01 mol %是可行的。 喹啉还原的机理研究表明，转移氢化通过1，2-和1，4-加成途径进行，催化周转受到氢化物转移步骤的限制。
A cyclometalated iridium complex is shown to catalyse the transfer hydrogenation of various nitrogen heterocycles, including but not limited to quinolines, isoquinolines, indoles and pyridinium salts, in an aqueous solution of HCO2H/HCO2Na under mild conditions. The catalyst shows excellent functional‐group compatibility and high turnover number (up to 7500), with catalyst loadings as low as 0.01 mol % being feasible. Mechanistic investigation of the quinoline reduction suggests that the transfer hydrogenation proceeds via both 1,2‐ and 1,4‐addition pathways, with the catalytic turnover being limited by the step of hydride transfer.