The Identification of Hereditary and Environmental Determinants of Frailty in a Cohort of UK Twins
The Identification of Hereditary and Environmental Determinants of Frailty in a Cohort of UK Twins
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DOI：
10.1017/thg.2016.72
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发表时间：
2016-12-01
影响因子：
0.9
通讯作者：
Steves, Claire J.
中科院分区：
文献类型：
--
作者：
Young, Aideen C. M.;Glaser, Karen;Steves, Claire J.
我们的研究探讨了遗传和环境因素（包括共享和独特）对脆弱性的贡献，使用罗克伍德脆弱指数（FI）对来自St托马斯' UK成人双胞胎登记处的双胞胎样本进行测量。FI基于39项潜在健康缺陷。研究参与者是3,375名40.0-84.5岁的志愿成年双胞胎（840对单卵双胞胎和802对双卵双胞胎）。首先，我们使用结构方程模型来估计遗传学和共享和独特的环境对年龄调整后的FI方差的相对贡献。在第二次分析中，使用多元线性回归来检查FI的方差作为父亲职业类别的函数（共享环境的组成部分和儿童社会经济地位[SES]的测量），调整年龄，出生体重，婚姻状况和健康行为（吸烟，饮酒和体育活动）。使用IBM SPSS（R）版本22软件和Mx开源软件进行统计分析。结果表明，45%（95%置信区间[CI] 30-53%）的个体间FI变异是可遗传的，52%（95% CI 47-57%）是由于个体的独特环境。多元线性回归也显示了一个小的，但统计上显着的负相关父亲的职业类和FI，介导的一个自己的教育程度和出生体重。我们的研究结果表明，脆弱性是遗传和环境决定的。因此，其预防和管理要求采取多方面的方法，包括解决有害的环境因素，其中一些因素，如儿童社会经济地位，可能会在整个生命过程中发挥作用。
Our study examines the contribution of genetic and environmental factors (both shared and unique) to frailty, measured using the Rockwood Frailty Index (FI) in a sample of twins from the St Thomas' UK Adult Twin Registry. The FI was based on 39 items of potential health deficit. Study participants were 3,375 volunteer adult twins (840 monozygotic and 802 dizygotic twin-pairs) 40.0-84.5 years old. First, we used structural equation modeling to estimate the relative contribution of genetics and of the shared and unique environment to variance in FI adjusted for age. In a second analysis, multiple linear regression was used to examine variance in FI as a function of father's occupational class (a component of shared environment and a measure of childhood socioeconomic status [SES]), adjusting for age, birth weight, marital status, and health behaviors (smoking, alcohol consumption, and physical activity). Statistical analyses were conducted using IBM SPSS (R) Version 22 software and Mx open source software. Findings showed that 45% (95% confidence intervals [CIs] 30-53%) of the inter-individual variation in FI was heritable and 52% (95% CIs 47-57%) was due to the individual's unique environment. Multiple linear regression also showed a small but statistically significant inverse association between father's occupational class and FI, mediated by one's own educational attainment and birth weight. Our results indicate that frailty is both genetically and environmentally determined. Thus, its prevention and management call for a multifaceted approach that includes addressing deleterious environmental factors, some of which, like childhood SES, may act across the life course.