Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis
Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis
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DOI：
10.21873/anticanres.13841
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发表时间：
2019-11-01
影响因子：
2
通讯作者：
Yoon, Sun Och
中科院分区：
文献类型：
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作者：
Cho, Yoon Ah;Kim, Eun Kyung;Yoon, Sun Och
背景/目的：尽管淋巴结转移相对较大，但口咽鳞状细胞癌（OPSCC）在临床上可能无法检测到。在这里，我们的目的是阐明 p16 表达与上皮间质转化 (EMT) 标记物的相关性。患者和方法：分析中包括根治性切除的 121 个 OPSCC 和 270 个非 OPSCC 组织样本，并进行了 p16、Twist 和 Snail/Slug 免疫组织化学分析。结果：与非 OPSCC 相比，OPSCC 与淋巴管侵犯、淋巴结转移、淋巴结转移灶最大直径较大和 p16 表达显着相关。此外，p16 表达与 Twist 和 Snail/Slug 的高表达相关。结论：OPSCC 中 EMT 标志物（如 Twist 和 Snail/Slug）的表达与 p16 表达相关。这可能表明 OPSCC 中的 HPV 感染改变了 EMT 标记物的表达并导致转移。
Background/Aim: Oropharyngeal squamous cell carcinoma (OPSCC) could be clinically undetectable despite the relatively large size of lymph node metastases. Here, we aimed to elucidate the correlation of p16 expression with epithelial-to-mesenchymal transition (EMT) markers. Patients and Methods: Radically resected 121 OPSCC and 270 non-OPSCC tissue samples were included in the analysis, and p16, Twist, and Snail/Slug immunohistochemistry was performed. Results: Compared to non-OPSCCs, OPSCCs were significantly associated with lymphovascular invasion, lymph node metastasis, larger maximal diameter of metastatic foci in the lymph nodes, and p16 expression. In addition, p16 expression correlated with high Twist and Snail/Slug expression. Conclusion: Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC. This might indicate that HPV infection in OPSCCs alters the expression of EMT markers and results in metastases.