Lysolipids in Vascular Development, Biology, and Disease.
Lysolipids in Vascular Development, Biology, and Disease.
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溶脂在血管发育、生物学和疾病中的作用。
DOI：
10.1161/atvbaha.120.305565
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Hla T
中科院分区：
文献类型：
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作者：
Engelbrecht E;MacRae CA;Hla T
膜磷脂代谢形成溶血磷脂，它具有独特的生化和生物物理性质，影响膜的结构和动力学。然而，溶血磷脂也可以作为G蛋白偶联受体的配体，影响胚胎发育、出生后生理和疾病。溶血磷脂酸(LPA)和鞘氨醇1-磷酸(S1P)这两种被研究最多的物种与血管发育、生理和心血管疾病特别相关。本文综述了LPA和S1P在血管发育过程中的作用、血管内皮细胞生物学及其在心血管疾病过程中的作用。此外，我们还指出了溶血磷脂生物学与Wnt途径之间的明显联系，Wnt途径是一个进化保守的基本发育信号系统。溶血磷脂信号系统的组成部分是心血管疾病的关键遗传决定因素，这一发现证明了该领域当前和未来的研究。随着调节溶血磷脂信号的药理学方法进入临床领域，该领域的新发现有望影响心血管疾病的新治疗策略。
Membrane phospholipid metabolism forms lysophospholipids, which possess unique biochemical and biophysical properties that influence membrane structure and dynamics. However, lysophospholipids also function as ligands for G protein-coupled receptors that influence embryonic development, postnatal physiology and disease. The two most well-studied species - lysophosphatidic acid (LPA) and sphingosine 1-phophosphate (S1P) are particularly relevant to vascular development, physiology and cardiovascular diseases. This review summarizes the role of LPA and S1P in vascular developmental processes, endothelial cell biology and their roles in cardiovascular disease processes. In addition, we also point out the apparent connections between lysophospholipid biology and the Wnt pathway, an evolutionarily-conserved fundamental developmental signaling system. The discovery that components of the lysophospholipid signaling system are key genetic determinants of cardiovascular disease has warranted current and future research in this field. As pharmacological approaches to modulate lysophospholipid signaling have entered the clinical sphere, new findings in this field promises to influence novel therapeutic strategies in cardiovascular diseases.