Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
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DOI：
10.1073/pnas.0806485105
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发表时间：
2008-10-14
影响因子：
11.1
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Gogtay, Nitin;Lu, Allen;Thompson, Paul M.
早期的研究表明，在儿童期精神分裂症（COS）中，发育中的大脑的外侧和内侧表面都存在进行性皮质灰质（GM）损失。在这里，我们使用基于张量的形态测量术来可视化COS中整个大脑的白质（WM）生长异常。利用高维弹性图像配准，我们在分析12名COS患者和12名年龄、性别和扫描间隔匹配的健康对照者的纵向脑mri的基础上，比较了COS患者和健康儿童5年期间局部WM生长速度的3D地图。在WM中，COS患者的年增长率比健康对照组低2.2% （P = 0.02，所有P值都经过校正）。差异最大的是右半球（P = 0.006）。这种不对称可归因于COS患者右半球生长速度慢于左半球生长速度（P = 0.037），但在健康对照中并非如此。健康对照组的WM增长率达到每年2.6% （P = 0.0002）。COS患者左半球每年仅增长1.3% （P = 0.066）。在COS中，WM生长速率与儿童整体评估量表的改善相关（R = 0.64, P = 0.029）。在COS患者中，整个大脑的生长速度都降低了，但这一过程似乎是以前到后（额-顶叶）的方式进行的，这种影响与低智商无关。生长速度与功能预后相关，并以详细的3D地图可视化。最后，这些发现还证实，精神分裂症中出现的进行性基因缺陷并不是WM过度生长的结果。
Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white matter (WM) growth abnormalities in COS throughout the brain. Using high-dimensional elastic image registration, we compared 3D maps of local WM growth rates in COS patients and healthy children over a 5-year period, based on analyzing longitudinal brain MRIs from 12 COS patients and 12 healthy controls matched for age, gender, and scan interval. COS patients showed up to 2.2% slower growth rates per year than healthy controls in WM (P = 0.02, all P values corrected). The greatest differences were in the right hemisphere (P = 0.006). This asymmetry was attributable to a right slower than left hemisphere growth rate mapped in COS patients (P = 0.037) but not in healthy controls. WM growth rates reached 2.6% per year in healthy controls (P = 0.0002). COS patients showed only a 1.3% per year trend for growth in the left hemisphere (P = 0.066). In COS, WM growth rates were associated with improvement in the Children's Global Assessment Scale (R = 0.64, P = 0.029). Growth rates were reduced throughout the brain in COS, but this process appeared to progress in a front-to-back (frontal-parietal) fashion, and this effect was not attributable to lower IQ. Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth.