The role of complement in nonalcoholic fatty liver disease.
The role of complement in nonalcoholic fatty liver disease.
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补体在非酒精性脂肪肝中的作用
DOI：
10.3389/fimmu.2022.1017467
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
非酒精性脂肪肝（NAFLD）已成为全球慢性肝病的主要原因。NAFLD包括一系列肝脏表现，从肝脏脂肪变性开始，并可能演变为非酒精性脂肪性肝炎、肝硬化甚至肝细胞癌。NAFLD的发病机制尚不完全清楚，但胰岛素抵抗和脂代谢紊乱与其密切相关。补体系统是免疫系统的重要组成部分，但它也参与脂质代谢。特别是，补体旁路途径的激活和补体激活产物如C3a、C3adesArg（酰化刺激蛋白或ASP）和C5a的产生与胰岛素抵抗、脂质代谢紊乱和肝脏炎症密切相关。本文就补体系统在NAFLD中的作用作一综述，旨在为开发NAFLD的新治疗策略提供依据。
Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved in lipid metabolism. In particular, activation of the alternative complement pathway and the production of complement activation products such as C3a, C3adesArg (acylation stimulating protein or ASP) and C5a, are strongly associated with insulin resistance, lipid metabolism disorder, and hepatic inflammation. In this review, we briefly summarize research on the role of the complement system in NAFLD, aiming to provide a basis for the development of novel therapeutic strategies for NAFLD.