Development of the Terumo Capiox centrifugal pump and its clinical application to open heart surgery: a comparative study with the roller pump.
Development of the Terumo Capiox centrifugal pump and its clinical application to open heart surgery: a comparative study with the roller pump.
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Terumo Capiox 离心泵的开发及其在心脏直视手术中的临床应用：与滚子泵的比较研究。
DOI：
10.1111/j.1525-1594.1993.tb00588.x
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发表时间：
2008
影响因子：
2.4
通讯作者：
H. Fukasawa
中科院分区：
文献类型：
--
作者：
H. Nishida;F. Yamaki;H. Nakatani;M. Endo;H. Koyanagi;H. Oshiyama;K. Horiuchi;T. Kijima;C. Nojiri;H. Fukasawa
我们开发了Terumo Capiox离心泵（CXP），该泵由具有独特直线路径设计的转子组成，可在不降低液压效率的情况下降低泵转速。使用新鲜牛血，通过专门设计的试验回路，在体外对CXP进行了血液创伤试验。生物泵（BP）（Medtronic，Minneapolis，MN，U.S.A.）和滚子泵（RP）用作对照。与BP和RP相比，CXP显示游离血浆血红蛋白升高最小。将CXP应用于10例择期冠状动脉旁路移植术（CABG）患者的体外循环（CPB）中（CXP组），并与可比较的滚压泵组（RP组）的结果进行比较。CPB期间测定血浆游离血红蛋白水平、血小板计数和血清β-血栓球蛋白（β-TG）水平。CPB期间无CXP相关并发症或血流动力学异常。与RP组相比，CXP组表现出更少的溶血和更少的血小板消耗。此外，血清β-TG水平在CXP组中显著低于RP组。CXP在体外和临床应用中均显示出良好的血流动力学性能和较少的血液创伤。因此，CXP具有安全应用于CPB进行心脏直视手术和循环支持的显著潜力。
We have developed the Terumo Capiox centrifugal pump (CXP), which consists of a rotor having a unique straight-path design to reduce pump rotational speed without decreasing hydraulic efficiency. The CXP was tested in vitro for blood trauma with a specially designed test circuit using fresh bovine blood. The Biopump (BP) (Medtronic, Minneapolis, MN, U.S.A.) and the roller pump (RP) were used as controls. The CXP demonstrated the smallest elevation of free plasma hemoglobin compared with the BP and the RP. The CXP was then applied to cardiopulmonary bypass (CPB) in 10 patients (CXP group) who underwent elective coronary artery bypass grafting (CABG), and the results were compared with those for a comparable roller pump group (RP group). Free plasma hemoglobin level, platelet count, and serum beta-thromboglobulin (beta-TG) level were measured during CPB. There were no CXP-related complications nor hemodynamic abnormalities during CPB. The CXP group demonstrated less hemolysis and less platelet depletion than the RP group. Furthermore, the serum beta-TG level was significantly lower in the CXP group than in the RP group. The CXP showed excellent hemodynamic performance with less blood trauma both in vitro and in clinical application to open heart surgery. Thus, the CXP has significant potential to be safely applied to CPB for open heart surgery and circulatory support.