Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human
Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human
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感染人类的卢西塔尼亚念珠菌对两性霉素 B 产生耐药性
DOI：
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发表时间：
1979
影响因子：
4.9
通讯作者：
Jack S. Remington
中科院分区：
文献类型：
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作者：
Demosthenes Pappagianis;M. Collins;Richard F. Hector;Jack S. Remington
1例急性髓性白血病患者感染相关的卢西塔念珠菌在患者全身治疗期间对两性霉素B产生耐药性。最初分离时，在酵母氮基琼脂中两性霉素B的抑制作用为0.31 μg/ml，但在死前和死后分离（20天后）时，48 h时两性霉素B的抑制作用分别为100和50 μg/ml。
Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 μg of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 μg/ml, respectively, for complete inhibition at 48 h.