Lithium does not synergize the peripheral action of cholinomimetics as seen in the central nervous system.
Lithium does not synergize the peripheral action of cholinomimetics as seen in the central nervous system.
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DOI：
10.1016/s0024-3205(01)00994-8
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发表时间：
2001-03
期刊：
影响因子：
6.1
通讯作者：
G. Chaudhary;Y. Gupta
中科院分区：
文献类型：
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作者：
G. Chaudhary;Y. Gupta
已知锂可协同拟胆碱药在中枢神经系统中的作用，使得毛果芸香碱在低浓度（本身剂量的1/13）下诱导大鼠癫痫发作。本研究旨在观察锂引发是否也增强乙酰胆碱和毛果芸香碱的外周效应，即大鼠血压变化和豚鼠离体回肠收缩。在麻醉大鼠中，通过压力传感器连接到Coulbourn多导生理记录仪，从插管的颈动脉记录血压。与对照组相比，氯化锂（3 meq/kg）预处理后1、2和4 h，匹鲁卡品的血压反应在幅度或持续时间上均无差异。类似地，氯化锂引发后乙酰胆碱效应保持不变。在离体豚鼠回肠实验中，将回肠在不同浓度的氯化锂中孵育1h，观察对乙酰胆碱引起的收缩的影响。浓度为2.8 × 10− 3 M的锂对乙酰胆碱引起的收缩没有影响，而与更高浓度的1.4 × 10− 2 M和2.8 × 10− 2 M孵育，观察到乙酰胆碱收缩的显著抑制。在该浓度下，组胺诱导的收缩也被抑制。结果表明，锂不能协同拟胆碱药在外周的作用，如在中枢神经系统中所见。高浓度锂对乙酰胆碱和组胺引起的豚鼠回肠收缩的抑制作用似乎是非特异性的。
Lithium is known to synergize the action of cholinomimetics in the CNS such that pilocarpine induces seizures in low concentration (1/13th of per se dose) in rats. The present study was undertaken to see if lithium priming also enhances the peripheral effects of acetylcholine and pilocarpine i.e. change in blood pressure in rats and contractions of the isolated guinea pig ileum. In anaesthetized rats the blood pressure was recorded from cannulated carotid artery connected through the pressure transducer to Coulbourn polygraph. The blood pressure response of pilocarpine was not different either in magnitude or in duration when administered 1, 2 and 4 h after lithium chloride (3meq/kg) pretreatment as compared to the control. Similarly acetylcholine effect remained unchanged after lithium chloride priming. In the isolated guinea pig ileum experiments, ileum was incubated for 1 h in different concentrations of lithium chloride and effect on acetylcholine induced contractions were observed. Lithium in concentration of 2.8 × 10−3M had no effect on acetylcholine induced contractions while incubation with higher concentrations of 1.4 × 10−2M and 2.8 × 10−2M significant inhibition of acetylcholine contractions were observed. At this concentration, histamine induced contractions were also inhibited. The results indicate that lithium does not synergize the action of cholinomimetics in the periphery as that seen in the CNS. The inhibition of acetylcholine and histamine induced contractions in guinea pig ileum at high concentration of lithium seems to be non-specific effect.