Nanogel‐Templated Mineralization: Polymer‐Calcium Phosphate Hybrid Nanomaterials
Nanogel‐Templated Mineralization: Polymer‐Calcium Phosphate Hybrid Nanomaterials
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DOI：
10.1002/marc.200500778
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发表时间：
2006-03
影响因子：
4.6
通讯作者：
Ayae Sugawara;S. Yamane;K. Akiyoshi
中科院分区：
文献类型：
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作者：
Ayae Sugawara;S. Yamane;K. Akiyoshi
摘要：我们报道了由聚合物水凝胶纳米颗粒（纳米凝胶）和磷酸钙组成的新型有机-无机杂化纳米材料。测量钙的混合纳米颗粒。使用纳米凝胶作为磷酸钙矿化的模板，从羟基磷灰石的稀溶液合成40 nm。这些纳米颗粒显示出窄的尺寸分布和高的胶体稳定性。纳米凝胶吸附的脂质体作为模板的分层混合纳米结构。这些纳米杂化物可以潜在地用作具有控制释放特性的生物相容性药物载体。在CHP纳米凝胶（0.5 mg · mL−1）（左）和纳米凝胶-脂质体（CHP 0.05 mg·mL −1，DPPC 0.08 mg · mL−1）（右）存在下形成的磷酸钙纳米颗粒的TEM图像。
Summary: We report novel organic-inorganic hybrid nanomaterials that consist of polymer hydrogel nanoparticles (nanogels) and calcium phosphate. Hybrid nanoparticles that measure ca. 40 nm are synthesized from a dilute solution of hydroxyapatite using nanogels as templates for calcium phosphate mineralization. These nanoparticles show a narrow size distribution and high colloidal stability. Nanogel-adsorbed liposomes act as templates for hierarchical hybrid nanostructures. These nanohybrids can potentially be used as biocompatible drug carriers with controlled-release properties. TEM images of calcium phosphate nanoparticles formed in the presence of CHP nanogels (0.5 mg · mL−1) (left) and nanogel-liposomes (CHP 0.05 mg · mL−1, DPPC 0.08 mg · mL−1)(right).