NEUROPSYCHOLOGICAL FUNCTION IN PATIENTS WITH END-STAGE HEART-FAILURE BEFORE AND AFTER CARDIAC TRANSPLANTATION
NEUROPSYCHOLOGICAL FUNCTION IN PATIENTS WITH END-STAGE HEART-FAILURE BEFORE AND AFTER CARDIAC TRANSPLANTATION
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DOI：
10.1111/j.1600-0404.1995.tb07001.x
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发表时间：
1995-04-01
影响因子：
3.5
通讯作者：
HAAS, GJ
中科院分区：
文献类型：
--
作者：
BORNSTEIN, RA;STARLING, RC;HAAS, GJ
本研究的目的是检查终末期心力衰竭患者的认知功能，确定与认知功能相关的可能的心血管因素，并评估接受心脏移植的患者亚组认知功能的变化。作为心脏移植评估的一部分，对 62 名终末期心力衰竭患者进行了一系列广泛的神经心理学测试。大多数患者是连续转诊的，由于认知问题而未被选择。一小部分移植患者 (n = 7) 和非移植患者 (n = 4) 接受了重复的神经心理学检查。初步检查时，大约 50% 的患者符合正常对照值的损伤标准。较高的每搏输出量指数和心脏指数以及较低的右心房压力与较好的认知功能相关。在重新检查的患者亚组中，移植患者的认知功能显着改善，而未移植受试者则没有变化。这些数据表明，在终末期心力衰竭患者中，认知功能受损的患病率很高，这与心血管效率的测量有关。初步证据表明，心脏移植可以部分改善这些损伤。
This study was performed to examine cognitive function in patients with end-stage heart failure, to identify possible cardiovascular factors associated with cognitive function, and to evaluate changes in cognitive function in a subgroup of patients who received heart transplantation. An extensive battery of neuropsychological tests were given to 62 patients with end-stage cardiac failure as part of their evaluation for cardiac transplantation. Most patients were consecutive referrals, not selected because of cognitive complaints. A small subgroup of transplanted (n = 7) and non-transplanted (n = 4) patients received a repeat neuropsychological examination. At initial examination, approximately 50% of the patients met criteria for impairment in reference to normal control values. Higher stroke volume index and cardiac index and lower right atrial pressure were correlated with better cognitive function. In the subgroup of patients re-examined, the transplanted patients demonstrated significantly improved cognitive function, whereas the non-transplanted subjects were unchanged. These data indicate that in patients with end-stage heart failure there is a high prevalence of impaired cognitive function which is related to measures of cardiovascular efficiency. Preliminary evidence suggests that these impairments may be partially ameliorated by cardiac transplantation.