Dissociation between the effects of damage to perirhinal cortex and area TE
Dissociation between the effects of damage to perirhinal cortex and area TE
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DOI：
10.1101/lm.6.6.572
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发表时间：
1999-11-01
影响因子：
2
通讯作者：
Zola, SM
中科院分区：
文献类型：
--
作者：
Buffalo, EA;Ramus, SJ;Zola, SM
嗅周皮层和TE区在颞叶中彼此紧邻，并相互连接，这些区域被认为位于视觉感知和视觉记忆之间的界面，但目前尚不清楚它们各自的贡献。在三个实验中，双侧病变的嗅周皮质的猴子表现出不同的模式的损害比猴子双侧病变的TE区。在实验1中，病变的嗅周皮层产生的多模态缺陷识别记忆（延迟不匹配的样品），而病变的TE区受损的性能只在视觉方式。在实验2中，在视觉识别记忆（视觉配对比较任务）的测试中，嗅周皮层的损伤在长时间延迟时损害了性能，但在很短的延迟时却没有影响性能。相比之下，TE区的病变损害的性能，即使在短的延迟。在实验3中，嗅周皮层的损伤和TE区的损伤在两个视觉辨别任务中产生了相反的损害模式，简单物体辨别学习（仅受嗅周病变影响），以及同时辨别学习（仅受TE损伤影响），总的来说，研究结果表明，嗅周皮层，像其他内侧颞叶结构一样，对记忆的形成很重要，而区域TE对于视觉感知处理是重要的。
Perirhinal cortex and area TE are immediately adjacent to each other in the temporal lobe and reciprocally interconnected, These areas are thought to lie at the interface between visual perception and visual memory, but it has been unclear what their separate contributions might be. In three experiments, monkeys with bilateral lesions of the perirhinal cortex exhibited a different pattern of impairment than monkeys with bilateral lesions of area TE. In experiment 1, lesions of the perirhinal cortex produced a multimodal deficit in recognition memory (delayed nonmatching to sample), whereas lesions of area TE impaired performance only in the visual modality. In experiment 2, on a test of visual recognition memory (the visual paired comparison task) lesions of the perirhinal cortex impaired performance at long delays but spared performance at a very short delay. In contrast, lesions of area TE impaired performance even at the short delay. In experiment 3, lesions of the perirhinal cortex and lesions of area TE produced an opposite pattern of impairment on two visual discrimination tasks, simple object discrimination learning (impaired only by perirhinal lesions), and concurrent discrimination learning (impaired only by TE lesions), Taken together, the findings suggest that the perirhinal cortex, like other medial temporal lobe structures, is important for the formation of memory, whereas area TE is important for visual perceptual processing.