SURVIVAL OF OXYGENATED AND HYPOXIC TUMOR-CELLS IN THE EXTENDED-PEAK REGIONS OF HEAVY CHARGED-PARTICLE BEAMS
SURVIVAL OF OXYGENATED AND HYPOXIC TUMOR-CELLS IN THE EXTENDED-PEAK REGIONS OF HEAVY CHARGED-PARTICLE BEAMS
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DOI：
10.2307/3575707
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
LYMAN, JT
中科院分区：
文献类型：
--
作者：
CURTIS, SB;SCHILLING, WA;LYMAN, JT
在悬浮培养的R-1大鼠横纹肌肉瘤细胞系中，在平台的几个位置以及C、Ne和Ar离子束的扩展峰区测量了氧合和缺氧细胞的存活率。C束和Ne束在水中的射程分别为14厘米和23厘米；而Ar光束的射程为13厘米。研究了每种离子的峰宽分别为4 cm和10 cm。在10 cm的扩展峰中，碳离子束的OER值接近2.0，霓离子束的OER值接近1.9-1.5，Ar离子束的OER值接近1.4-1.2。Ne离子在扩展峰中的OER[O2增强比]与中子相似，而在扩展峰中的Ar OER低于中子。相对生物效应值在C峰区增大，在N峰区较大且相对恒定，在Ar峰区减小，反映了有效LET的变化。[线性能量转移]这是由粒子的能量变化和不同的电荷引起的。对不同的离子束对高峰期低氧细胞的杀灭效果的分析表明，对于单端口照射，C离子可能是治疗深层低氧肿瘤最有利的带电粒子物种。然而，对于浅部肿瘤，目前的结果表明C和Ne离子的效果相似。对于体表附近含氧量低的肿瘤，Ar离子的治疗效果可能更好。
The survival of oxygenated and hypoxic cells of the R-1 rat rhabdomyosarcoma tumor line in suspension culture has been measure at several positions in the plateau and the extended-peak regions of C-, Ne-, and Ar-ion beams. Both the C and Ne beams had 14- and 23-cm ranges in water; the Ar beam had a 13-cm range. Peak regions extended to both 4 and 10 cm were studied for each ion species. In the 10-cm extended peak, OER values were close to 2.0 for the C-ion beam, 1.9-1.5 for the neon beam, and 1.4-1.2 for the Ar-ion beam. The OER [O2 enhancement ratio] of neon ions in the extended peak is similar to that found for neutrons, while the Ar OER in the extended peak is lower than that for neutrons. The RBE [relative biological effectiveness] values increased through the C peak region, were large and relatively constant through the N peak region, and decreased through the Ar peak region, thus reflecting the changing effective LET .infin. [linear energy transfer] that results from the changing energies and the different charges of the particles. An analysis of the effectiveness of the different ion beams for killing hypoxic cells in the peak relative to killing oxygenated cells in the plateau implies that, for single-port irradiations, C ions may be the most advantageous charged-particle species for the treatment of deep-seated hypoxic tumors. However, for tumors at shallow depths, the present results indicate that C and Ne ions are similar in their effectiveness. Ar ions may be superior for the treatment of poorly oxygenated tumors close to the body surface.