Degradation of mouse locomotor pattern in the absence of proprioceptive sensory feedback
Degradation of mouse locomotor pattern in the absence of proprioceptive sensory feedback
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DOI：
10.1073/pnas.1419045111
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发表时间：
2014-11-25
影响因子：
11.1
通讯作者：
Jessell, Thomas M.
中科院分区：
文献类型：
--
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
哺乳动物的运动程序被认为是由统称为“中央模式发生器”的脊髓中间神经元回路的动作指导的。“本体感觉反馈对运动活动协调的贡献仍然不太清楚。我们分析了小鼠运动模式的变化条件下，本体感受反馈衰减遗传和生物力学。我们发现，运动模式退化消除后，从肌梭和高尔基体腱器官的本体感受反馈。运动模式的退化表现为关节间协调性的丧失和屈伸肌的交替。组Ia/II的感觉反馈肌梭有一个主要的影响，在图案的活动屈肌，而冗余的活动组Ia/II和组Ib传入似乎决定模式的伸肌放电。这些发现确立了本体感受反馈在控制哺乳动物运动行为的基本方面中的作用。
Mammalian locomotor programs are thought to be directed by the actions of spinal interneuron circuits collectively referred to as "central pattern generators." The contribution of proprioceptive sensory feedback to the coordination of locomotor activity remains less clear. We have analyzed changes in mouse locomotor pattern under conditions in which proprioceptive feedback is attenuated genetically and biomechanically. We find that locomotor pattern degrades upon elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs. The degradation of locomotor pattern is manifest as the loss of interjoint coordination and alternation of flexor and extensor muscles. Group Ia/II sensory feedback from muscle spindles has a predominant influence in patterning the activity of flexor muscles, whereas the redundant activities of group Ia/II and group Ib afferents appear to determine the pattern of extensor muscle firing. These findings establish a role for proprioceptive feedback in the control of fundamental aspects of mammalian locomotor behavior.