Treatment of ranula with intracystic injection of the streptococcal preparation OK-432
Treatment of ranula with intracystic injection of the streptococcal preparation OK-432
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DOI：
10.1177/000348940311200304
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发表时间：
2003-03-01
影响因子：
1.4
通讯作者：
Aoyagi, M
中科院分区：
文献类型：
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作者：
Fukase, S;Ohta, N;Aoyagi, M
囊内注射 OK-432 是作为手术困难的淋巴管瘤（囊性水瘤）的治疗方法而开发的，目前正成为该疾病的首选治疗方法。我们对 32 例毛囊患者尝试了这种疗法（口腔底型 21 例，插入型 11 例）。接受该疗法的 31 名患者（97%）观察到病变消失或明显缩小，并且没有任何患者出现局部疤痕。作为副作用，接受这种疗法的患者中几乎一半观察到注射部位的局部疼痛和发烧（37℃至39℃），但这些问题在几天内就消失了。最初的4例我们在医院治疗了4到5天，但在确认这种方法的安全性后，我们在门诊治疗了另外28例。因此，我们证实OK-432囊内注射治疗相对安全，可以替代手术治疗毛苋。
Intracystic injection of OK-432 was developed as a therapy for operatively difficult lymphangioma (cystic hygroma) and is currently becoming a treatment of first choice for this disease. We tried this therapy in 32 patients with ranula (oral floor type in 21 cases and plunging type in 11 cases). Disappearance or marked reduction of the lesion was observed in 31 patients (97%) who had this therapy, and local scarring did not occur in any patient. As side effects, local pain at the injection site and fever (37degreesC to 39degreesC) were observed in almost half of the patients who had this therapy, but such problems resolved within a few days. We treated the initial 4 cases in the hospital for 4 to 5 days, but after the safety of this method had been confirmed, we treated the other 28 cases on an outpatient basis. Thus, we confirmed that intracystic injection therapy with OK-432 is relatively safe and can be used as a substitute for surgery in the treatment of ranulas.