Oral Health Disorders in Parkinson's Disease: More than Meets the Eye.
Oral Health Disorders in Parkinson's Disease: More than Meets the Eye.
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DOI：
10.3233/jpd-212605
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Vérin M
中科院分区：
文献类型：
--
作者：
Auffret M;Meuric V;Boyer E;Bonnaure-Mallet M;Vérin M
尽管临床证据表明帕金森氏病(PD)患者口腔健康和卫生状况不佳，但口腔经常被患者和医学界忽视，他们通常关注被认为负担更重的运动或精神障碍。然而，口腔健康与整体健康是双向的关系--一种虚弱的状态会引发生活质量的下降。在这里，我们的目的是给出一个全面的概述口腔健康障碍的PD，同时确定其原因和后果。与帕金森病相关的身体(异常姿势、肌张力、震颤和运动障碍)、行为(认知和神经精神障碍)和医源性模式对患者的口腔健康产生全面有害影响，使他们面临其他疾病(感染、吸入、疼痛、营养不良)的风险，降低他们的生活质量，并增加他们的孤立(焦虑、抑郁、沟通问题)。需要在早期阶段实施跨学科合作的预防、管理和后续战略，以维持和改善患者的整体舒适度和状况。对实践的建议，包括(非)药理学管理策略被讨论，重点是神经学家的作用。值得注意的是，口腔在不久的将来可能成为诊断和预后的有价值的工具(生物标记物)。这个被忽视但至关重要的问题需要进一步的关注和跨学科的研究。
Despite clinical evidence of poor oral health and hygiene in Parkinson’s disease (PD) patients, the mouth is often overlooked by both patients and the medical community, who generally focus on motor or psychiatric disorders considered more burdensome. Yet, oral health is in a two-way relationship with overall health—a weakened status triggering a decline in the quality of life. Here, we aim at giving a comprehensive overview of oral health disorders in PD, while identifying their etiologies and consequences. The physical (abnormal posture, muscle tone, tremor, and dyskinesia), behavioral (cognitive and neuropsychiatric disorders), and iatrogenic patterns associated with PD have an overall detrimental effect on patients’ oral health, putting them at risk for other disorders (infections, aspiration, pain, malnutrition), reducing their quality of life and increasing their isolation (anxiety, depression, communication issues). Interdisciplinary cooperation for prevention, management and follow-up strategies need to be implemented at an early stage to maintain and improve patients’ overall comfort and condition. Recommendations for practice, including (non-)pharmacological management strategies are discussed, with an emphasis on the neurologists’ role. Of interest, the oral cavity may become a valuable tool for diagnosis and prognosis in the near future (biomarkers). This overlooked but critical issue requires further attention and interdisciplinary research.