Neuroticism is associated with challenging experiences with psilocybin mushrooms
Neuroticism is associated with challenging experiences with psilocybin mushrooms
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DOI：
10.1016/j.paid.2017.06.004
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发表时间：
2017-10-15
影响因子：
4.3
通讯作者：
Griffiths, Roland R.
中科院分区：
文献类型：
--
作者：
Barrett, Frederick S.;Johnson, Matthew W.;Griffiths, Roland R.
目的：经典的致幻剂（例如裸盖菇素和LSD）对感知，认知和情感有实质性的影响，这些影响通常具有心理挑战性，但是我们对致幻剂在挑战性体验（即“糟糕的旅行”）的频率和强度中观察到的显著个体差异的来源知之甚少。以前的临床和观察文献表明，可能有一个神经质和具有挑战性的迷幻experiences. Methods：从两个在线调查的挑战性的经验与psilocybin数据之间的关联进行了分析。采用多因素分析法对总分与七个因子分之间的关系进行分析在研究1中，研究者使用了生活经历问卷（CEQ）中的恐惧、悲伤、身体痛苦、精神错乱、孤独、死亡和偏执狂，以及十项人格问卷（TIPI）中的量表得分结果：CEQ得分与情绪稳定性得分呈显著负相关在研究1中，神经质与神经质得分呈负相关，在研究2中，神经质与神经质得分呈正相关。神经质可能有助于在不受控制的环境中挑战迷幻剂的经验。(C)2017爱思唯尔有限公司版权所有
Objectives: Classic hallucinogens (e.g. psilocybin and LSD) have substantial effects on perception, cognition, and emotion that can often be psychologically challenging, however we know very little regarding the source of significant individual variability that has been observed in the frequency and intensity of challenging experiences (i.e. "bad trips") with psychedelics. Previous clinical and observational literature suggests that there may be an association between neuroticism and challenging psychedelic experiences.Methods: Data from two online surveys of challenging experiences with psilocybin were analyzed. Multivariate analysis was used to estimate the associations between total score and scores from seven sub-factors (fear, grief, physical distress, insanity, isolation, death, and paranoia) of the Challenging Experience Questionnaire (CEQ), and scale scores from the Ten Item Personality Inventory (TIPI) in Study 1 (N = 1993) and the Big Five Inventory (BFI) in Study 2 (N = 981).Results: CEQ scores were negatively associated with emotional stability scores (the inverse of neuroticism) in Study 1 and positively associated with neuroticism scores in Study 2.Conclusions: Neuroticism may contribute to the strength of challenging experiences with psychedelics in uncontrolled settings. (C) 2017 Elsevier Ltd. All rights reserved.