Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version.
Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version.
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DOI：
10.1097/ypg.0000000000000154
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发表时间：
2017-02
影响因子：
0.9
通讯作者：
Britvić D
中科院分区：
文献类型：
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作者：
Kralj Ž;Dedić M;Kovačević A;Malički M;Dedić J;Pelivan M;Vuković D;Fisher C;Kember RL;Nurnberger J;Bućan M;Britvić D
在克罗地亚精神疾病患者中测试遗传研究诊断访谈（DIGS）的有效性和可靠性。翻译，回译和试点测试后，克罗地亚版本的DIGS（CRO-DIGS）管理，共150住院患者和门诊患者在斯普利特的临床医院诊断，双相和重度抑郁症（n=56），精神分裂症和分裂情感障碍（n=62），酒精依赖或使用障碍（n=32）。最初的测试由一名面试官和一名对诊断不知情的观察员独立进行，八周后由第三名检查员进行重新测试。CRO-DIGS的效度较高（κ = 0.916），评分员间信度（κ = 0.824）极佳，尤其是双相情感障碍（κ = 0.956）。在8周的重测间隔后，发现所有诊断的可靠性都很好（κ = 0.843）。我们的研究表明，克罗地亚版本的遗传研究诊断访谈的有效性和可靠性，使其成为一个有前途的工具，以评估患者的精神疾病。开发一种有效和可靠的诊断工具，如CRO-DIGS，将大大提高科学界对该区域精神疾病进行遗传研究的能力。
To test the validity and reliability of the Diagnostic Interview for Genetic Studies (DIGS) in patients with mental illness in Croatia. Following translation, back-translation and pilot-testing, the Croatian version of DIGS (CRO-DIGS) was administered to a total of 150 inpatients and outpatients diagnosed at the Clinical Hospital in Split, with Bipolar and Major depressive Disorder (n=56), Schizophrenia and Schizoaffective disorder (n=62), and Alcohol dependence or use disorders (n=32). Initial testing was performed independently by one interviewer and one observer blinded to the diagnosis, and a retest was conducted after eight weeks by a third examiner. Validity of CRO-DIGS was high (κ = 0.916) with an excellent inter-rater (κ = 0.824) reliability, especially for Bipolar disorder (κ = 0.956). Following an eight week test-retest interval, the reliability for all diagnoses was found to be excellent (κ = 0.843). Our study has shown excellent validity and reliability of the Croatian version of Diagnostic Interview for Genetic Studies, making it a promising instrument to assess mental illness of patients. The development of a valid and reliable diagnostic tool such as the CRO-DIGS will greatly advance the scientific communities’ ability to conduct genetic studies of psychiatric illness in the region.