Assessing the clinical and economic burden of coronary artery disease: 1986-1998
Assessing the clinical and economic burden of coronary artery disease: 1986-1998
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DOI：
10.1097/00005650-200108000-00008
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发表时间：
2001-08-01
期刊：
影响因子：
3
通讯作者：
Mark, DB
中科院分区：
文献类型：
--
作者：
Eisenstein, EL;Shaw, LK;Mark, DB
背景冠状动脉疾病（CAD）的急性期是引人注目的，并因其高死亡率和相关的治疗费用而受到广泛关注。然而，急性期通常在30天内消退，而CAD是一种慢性疾病，大多数患者将生活在十年以上。我们比较了急性期（前30天）和急性期后（第31天至10年）CAD的临床和经济负担。我们纳入了1986年至1997年间在杜克大学医学中心接受首次心导管插入术的严重CAD的急性冠状动脉综合征（ACS）患者，随访持续至1998年。根据ACS临床试验和经济学研究数据估计住院患者的医疗费用。成本按1997年的价值调整，并按每年3%的折扣率计算。我们的研究包括9，876名ACS患者（5，557名急性心肌梗死[MI]和4，319名不稳定型心绞痛[UA]）。急性心肌梗死患者的30天死亡率高于UA患者（5.6% vs. 2.3%，P
BACKGROUND. The acute phase of coronary artery disease (CAD) is dramatic and receives much attention because of its high mortality and associated treatment cost. However, the acute phase Typically resolves within 30 days whereas CAD is a chronic disease, which most patients will Live with for mare than a decade. We compared the clinical and economic burden of CAD during the acute phase (first 30 days) with that in The postacute phase (31st day through 10 years).METHODS. We included acute coronary syndrome (ACS) patients with significant CAD receiving an initial cardiac catheterization at Duke University Medical Center between 1986 and 1997 with follow-up continuing through 1998. Inpatient medical costs were estimated from ACS clinical trial and economic study data. Costs were adjusted to 1997 values and discounted at 3% per annum.RESULTS. Our study included 9,876 ACS patients (5,557 with an acute myocardial infarction [MI] anal 4,319 with unstable angina [UA]). Acute MI patients had higher 30-day mortality than UA patients (5.6% vs. 2.3%, P