Association of activated transcription factor nuclear factor κB with chemoradiation resistance and poor outcome in esophageal carcinoma
Association of activated transcription factor nuclear factor κB with chemoradiation resistance and poor outcome in esophageal carcinoma
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DOI：
10.1200/jco.2005.03.8810
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发表时间：
2006-02-10
影响因子：
45.3
通讯作者：
Ajani, JA
中科院分区：
文献类型：
--
作者：
Izzo, JG;Malhotra, U;Ajani, JA
目的：由于局限性食管癌缺乏有效的治疗方法，导致患者预后不良。核因子κ B患者和方法研究了来自参加临床试验的患者的治疗前和治疗后的癌症标本的活化NF-κ B蛋白的表达，并且其与组织学特征、病理反应、转移潜能、总生存期（OS）、结果43例患者接受相同的治疗方案。29例达到不完全病理学缓解（pathCB）的患者中有21例（72%）为NF-κ B阳性癌症，但14例达到pathCB的患者中仅1例（7%）为NF-κ B阳性癌症（P = 0.001）。
Purpose The lack of effective treatment for localized esosphageal cancer leads to poor patient outcome. Nuclear factor kappa B (NF-kappa B), a transcriptional factor, is constitutively activated or treatment induced in esophageal cancer and may influence treatment outcomes.Patients and Methods Pre- and post-treatment cancer specimens from patients enrolled onto a clinical trial were studied for the expression of activated NF-kappa B protein and it was correlated with histologic features, pathologic response, metastatic potential, overall survival (OS), and disease-free survival (DFS).Results Forty-three patients undergoing the same therapy on a protocol were studied. Twenty-one (72%) of 29 patients achieving less than complete pathologic response (pathCB) had NF-kappa B positive cancer, but only one (7%) of 14 patients achieving pathCB had NF-kappa B positive cancer (P =