Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers
Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers
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DOI：
10.1016/j.resp.2020.103429
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发表时间：
2020-06-01
影响因子：
2.3
通讯作者：
Ayuse, Takao
中科院分区：
文献类型：
--
作者：
Mishima, Gaku;Sanuki, Takuro;Ayuse, Takao
目的：在镇静过程中，通气不足和二氧化碳（CO2）潴留是常见的。方法：10名男性志愿者在清醒和镇静时分别以30 L/min和60 L/min的鼻腔高流量（nasal high flow，NHF）通气。通过呼吸感应体积描记法、经皮二氧化碳分压（TcCO 2）和SpO（2）监测通气。在镇静期间，30 L/min和60 L/min的NHF使TcCO 2降低了2.9 +/- 2.7 mmHg（p = 0.025）和3.6 +/- 3.4 mmHg（p = 0.024）而不影响SpO（2），平均呼吸频率降低3 +/- 3次/min结论：在丙泊酚镇静过程中，无辅助供氧的NHF可减少CO2潴留，降低呼吸频率。研究结果表明，NHF可以改善镇静期间的通气，这可能会降低与通气不足相关的并发症的风险。
Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol.Methods: NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2(TcCO2), and SpO(2).Results: During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO2 by 2.9 +/- 2.7 mmHg (p = 0.025) and by 3.6 +/- 3.4 mmHg (p = 0.024) without affecting SpO(2) and reduced the mean respiratory rate by 3 +/- 3 breaths/min (p = 0.011) and by 4 +/- 3 breaths/min (p = 0.003), respectively.Conclusion: During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.