Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action
Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action
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DOI：
10.1523/jneurosci.2399-18.2018
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发表时间：
2019-03-06
影响因子：
5.3
通讯作者：
Minamimoto, Takafumi
中科院分区：
文献类型：
--
作者：
Fujimoto, Atsushi;Hori, Yukiko;Minamimoto, Takafumi
处理激励和驱动力对于控制目标导向的行为至关重要。在这些过程中，基底神经节的边缘部分得到了强调，但确切的神经元机制仍然难以捉摸。在这项研究中，我们检查了腹侧苍白球（VP）及其上游区域，即嘴内侧尾状核（rmCD）的神经元活动，同时两只雄性猕猴执行了工具杠杆释放任务，其中视觉提示指示即将到来的奖励大小。我们发现 VP 和 rmCD 中一些神经元的活动反映了提示后短暂的预期奖励大小。奖励大小编码在 VP 中比在 rmCD 中出现更早、更强。我们还发现这些区域的活动受到猴子的饱腹感水平的调节，这种情况在 VP 中比在 rmCD 中更频繁地发生。有关奖励大小和饱腹感水平的信息在这些区域的神经元群体中独立发出信号。因此，这些数据强调了 VP 中目标导向行为的关键变量的神经元编码。此外，与 rmCD 失活相比，VP 的药物失活会导致更严重的目标导向行为缺陷，这表现为异常的错误重复和对表现的饱足感减弱。这些结果表明，VP 编码激励价值和内部驱动力，在控制动机以促进目标导向行为方面发挥着关键作用。
Processing incentive and drive is essential for control of goal-directed behavior. The limbic part of the basal ganglia has been emphasized in these processes, yet the exact neuronal mechanism has remained elusive. In this study, we examined the neuronal activity of the ventral pallidum (VP) and its upstream area, the rostromedial caudate (rmCD), while two male macaque monkeys performed an instrumental lever release task in which a visual cue indicated the forthcoming reward size. We found that the activity of some neurons in VP and rmCD reflected the expected reward size transiently following the cue. Reward size coding appeared earlier and stronger in VP than in rmCD. We also found that the activity in these areas was modulated by the satiation level of monkeys, which also occurred more frequently in VP than in rmCD. The information regarding reward size and satiation level was independently signaled in the neuronal populations of these areas. The data thus highlighted the neuronal coding of key variables for goal-directed behavior in VP. Furthermore, pharmacological inactivation of VP induced more severe deficit of goal-directed behavior than inactivation of rmCD, which was indicated by abnormal error repetition and diminished satiation effect on the performance. These results suggest that VP encodes incentive value and internal drive and plays a pivotal role in the control of motivation to promote goal-directed behavior.