Selective adhesion of cells from different telencephalic regions
Selective adhesion of cells from different telencephalic regions
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DOI：
10.1016/s0896-6273(00)80074-4
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发表时间：
1996-03-01
期刊：
影响因子：
16.2
通讯作者：
Price, J
中科院分区：
文献类型：
--
作者：
Gotz, M;Wizenmann, A;Price, J
我们问是否规范的不同地区的啮齿动物和鸟类端脑在发展过程中涉及收购的差异粘附性能。在短期聚集测定中聚集来自不同区域的细胞，并分析它们的分离。皮层神经元和前体细胞分离的纹状体细胞在早期，但不是后期，阶段，而啮齿动物的新皮层和海马分离的细胞只在后期阶段。分离被废除时，钙依赖性，但不依赖于钙离子的粘附分子被选择性地删除。因此，选择性粘附似乎是一种保守的机制，限制细胞混合，并可能有助于保持前脑发育过程中的位置信息。介导Ca 2+依赖性分离的候选者是CD 15（刘易斯（x））碳水化合物表位，其由哺乳动物皮质而非纹状体选择性表达。
We asked whether specification of different regions of the rodent and avian telencephalon during development involved the acquisition of differential adhesive properties. Cells from different regions were aggregated in a short-term aggregation assay, and their segregation was analyzed. Both neurons and precursor cells from cortex segregate from striatal cells at early, but not later, stages, whereas cells from rodent neocortex and hippocampus segregated only during later stages. Segregation was abolished when Ca2+-dependent but not Ca2+-independent adhesion molecules were selectively removed. Thus, selective adhesion appears to be a conserved mechanism that restricts cellular mixing and might serve to maintain positional information during forebrain development. A candidate for mediating the Ca2+-dependent segregation is the CD15 (Lewis(x)) carbohydrate epitope, which is selectively expressed by mammalian cortex but not striatum.