Clinical Significance of Red Cell Distribution Width and Circulating Tumor Cells with an Epithelial-Mesenchymal Transition Phenotype in Lung Adenocarcinoma
Clinical Significance of Red Cell Distribution Width and Circulating Tumor Cells with an Epithelial-Mesenchymal Transition Phenotype in Lung Adenocarcinoma
复制标题
肺腺癌中红细胞分布宽度和具有上皮-间质转化表型的循环肿瘤细胞的临床意义
DOI：
10.2147/cmar.s251271
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发表时间：
2020-01-01
影响因子：
3.3
通讯作者：
Chen, Mingwu
中科院分区：
文献类型：
--
作者：
Peng, Huajian;Tan, Xiang;Chen, Mingwu
目的：确定具有上皮 - 间质转变表型（M-CTC）在肺腺癌（LUAD）中的红细胞分布宽度（RDW）和循环肿瘤细胞的预后值。患者和方法：收集60例LUAD患者的临床和实验室数据。使用CANPATROLTM CTC富集方法从其外周血中分离CTC。根据实验室标准，计算了RDW和中性粒细胞淋巴细胞比（NLR）的指标。结果：总共60名LUAD患者招募了，其中19名（31.7％）的RDW（> 0.14）和32（53.3％）为阳性form-CTC。 RDWAND之间没有显着的相关性。 M-CTC与肿瘤的大小和分化，年龄，性别，肿瘤分期和组织学类型没有显着相关，但与淋巴转移（P = 0.044），高NLR（> 2.26，P = 0.023）和高RDW（高RDW）显着相关（ > 0.14，p = 0.036）。此外，M-CTC+ LUAD患者的无复发生存率明显较差（RFS； log秩P = 0.001，HR = 2.749，95％CI = 1.489-5.078）和整体生存率（OS; log Cark P = 0.022，hr p = 0.022，hr = 0.022，hr与M-CTC-患者相比，= 2.283，95％CI = 1.128-4.622）。同样，高RDWALSO与较差的RF相关（log Cank P = 0.008，HR = 2.331，95％CI = 1.248-4.353）和OS（log Cark P = 0.004，HR = 0.004，95％CI = 1.398-5.525）。结论：M-CTC与RDW和NLR显着相关，并且在LUAD中是独立的预后因素。
Objective: To determine the prognostic value of red cell distribution width (RDW) and circulating tumor cells with epithelial-mesenchymal transition phenotype (M-CTC) in lung adenocarcinoma (LUAD). Patients and Methods: Clinical and laboratory data of 60 patients with LUAD were collected. CTCs were isolated from their peripheral blood using the CanPatrolTM CTC enrichment method. The indicators of RDW and neutrophil lymphocyte ratio (NLR) were calculated based on the laboratory standards. Results: A total of 60 LUAD patients were enrolled, of which 19 (31.7%) had high RDW (>0.14) and 32 (53.3%) were positive forM-CTCs. There was no significant correlation between RDWand the clinical characteristics. M-CTC was not significantly associated with tumor size and differentiation, age, gender, tumor stage, and histological type but correlated significantly with lymphatic metastasis (P = 0.044), high NLR (>2.26, P = 0.023), and high RDW (>0.14, P = 0.036). Furthermore, the M-CTC+ LUAD patients had a significantly poor recurrence-free survival (RFS; Log rank P =0.001, HR = 2.749, 95% CI = 1.489-5.078) and overall survival (OS; Log rank P =0.022, HR = 2.283, 95% CI = 1.128-4.622) compared to the M-CTC- patients. Similarly, high RDWalso correlated with worse RFS (Log rank P = 0.008, HR = 2.331, 95% CI = 1.248-4.353) and OS (Log rank P = 0.004, HR = 0.004, 95% CI = 1.398-5.525). Conclusion: M-CTC is significantly related to RDW and NLR, and an independent prognostic factor in LUAD.