Effect of Blood Collection Time on Measured Δ9-Tetrahydrocannabinol Concentrations: Implications for Driving Interpretation and Drug Policy
Effect of Blood Collection Time on Measured Δ9-Tetrahydrocannabinol Concentrations: Implications for Driving Interpretation and Drug Policy
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DOI：
10.1373/clinchem.2015.248492
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发表时间：
2016-02-01
影响因子：
9.3
通讯作者：
Huestis, Marilyn A.
中科院分区：
文献类型：
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作者：
Hartman, Rebecca L.;Brown, Timothy L.;Huestis, Marilyn A.
背景：在酒后驾驶的情况下，通常在事故发生后约 1.5-4 小时采集血液，最后一次采血时间未知。由于吸入后浓度立即迅速下降，这使得血液中 Delta(9)-四氢大麻酚 (THC) 的解释变得复杂。我们评估了采集前血液 THC 浓度的降低如何影响毒理学结果的解释。 方法：成年大麻吸烟者（>= 1 X /3 个月，= 8.2 mu/L）降至中位数
BACKGROUND: In driving-under-the-influence cases, blood typically is collected approximately 1.5-4 h after an incident, with unknown last intake time. This complicates blood Delta(9)-tetrahydrocannabinol (THC) interpretation, owing to rapidly decreasing concentrations immediately after inhalation. We evaluated how decreases in blood THC concentration before collection may affect interpretation of toxicological results.METHODS: Adult cannabis smokers (>= 1 X /3 months, = 8.2 mu/L) decreased to median