Lowered glucose suppressed the proliferation and increased the differentiation of murine neural stem cells in vitro
Lowered glucose suppressed the proliferation and increased the differentiation of murine neural stem cells in vitro
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DOI：
10.1016/j.febslet.2004.06.085
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发表时间：
2004-07-30
期刊：
影响因子：
3.5
通讯作者：
Shinohara, K
中科院分区：
文献类型：
--
作者：
Horie, N;Moriya, T;Shinohara, K
脑缺血可激活内源性神经干细胞（NSCs），但其机制尚不清楚。由于葡萄糖供应降低似乎介导缺血作用，我们在体外研究了低糖对NSC活性的影响。在增殖期低糖可抑制egf诱导的NSCs增殖，但不影响后续分化，而在分化期直接暴露低糖可促进NSCs向神经元和星形胶质细胞分化。这些结果表明，低糖促进了NSC的分化，但减少了NSC的增殖。此外，低糖的效果可能取决于应用的时间。(C) 2004年由Elsevier B.V.代表欧洲生化学会联合会出版。
Cerebral ischemia is known to activate endogenous neural stem cells (NSCs), but its mechanisms remain unknown. Since lowered glucose supply seems to mediate ischemic actions, we examined the effect of low glucose on NSC activities in vitro. Low glucose applied during the proliferation period diminished EGF-induced proliferation of NSCs without affecting subsequent differentiation, but low glucose directly exposed during the differentiation period facilitated the differentiation of NSCs into neurons and astrocytes. These findings suggest that low glucose facilitated NSC differentiation, but it diminished NSC proliferation. Moreover, the effect of low glucose may be dependent on the timing of application. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.