POLYMORPHISM OF DNA DOUBLE HELICES
POLYMORPHISM OF DNA DOUBLE HELICES
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DOI：
10.1016/0022-2836(80)90124-2
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发表时间：
1980-01-01
影响因子：
5.6
通讯作者：
RATLIFF, RL
中科院分区：
文献类型：
--
作者：
LESLIE, AGW;ARNOTT, S;RATLIFF, RL
纤维中的天然DNA双链体通常以3种众所周知的形式（A、B和C）中的一种存在，这取决于相对湿度、阳离子的类型和保留的盐的量。为了确定这些因素的精确影响和碱基组成的效果，和碱基序列，对DNA二级结构，X-射线衍射方法被用来研究所有4个重复的二核苷酸序列的合成DNA双链体，8个重复的三核苷酸序列的12个和7个类似物，其中鸟嘌呤被替换为次黄嘌呤。显然至少有6个附加的同素异形，分别用B“、C”、C”、D、E和S表示。
Native DNA duplexes in fibers exist usually in 1 of 3 well-known (A, B and C) forms depending on relative humidity, type of cations and the amount of retained salt. To determine the precise influence of these factors and the effect of base composition, and base sequence, on DNA secondary structure, X-ray diffraction methods were used to study all 4 synthetic DNA duplexes with repeated dinucleotide sequences, 8 of the 12 with repeated trinucleotide sequences and 7 analogs in which guanine was replaced with hypoxanthine. There are apparently at least 6 additional allomorphs denoted by B'', C'', C", D, E and S.