Maladaptive phenotypic plasticity in cardiac muscle growth is suppressed in high‐altitude deer mice
Maladaptive phenotypic plasticity in cardiac muscle growth is suppressed in high‐altitude deer mice
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DOI：
10.1111/evo.13626
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发表时间：
2018-11
期刊：
影响因子：
3.3
通讯作者：
Jonathan P. Velotta;C. Ivy;Cole J. Wolf;G. Scott;Z. Cheviron
中科院分区：
文献类型：
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作者：
Jonathan P. Velotta;C. Ivy;Cole J. Wolf;G. Scott;Z. Cheviron
表型可塑性多久起作用以促进或抑制适应性进化是生物学家之间持续的争论。最近的研究表明，适应性表型可塑性促进进化的分歧，虽然一些研究也表明，适应不良的可塑性可以加强适应。表型可塑性，适应性或适应不良，在进化分歧中的作用仍然存在争议。我们研究了可塑性在两种不同的本地海拔的Peromyscus小鼠之间的进化分歧的作用。我们使用心脏质量作为模型表型，因为祖先缺氧诱导的心脏反应在高海拔地区可能是适应性和适应不良的。虽然左心室的生长应该增加组织的氧气输送，但右心室的肥大可能导致心力衰竭和死亡。我们比较了人工饲养的白背飞虱（代表祖先的低地条件）和来自高海拔地区的马尼拉飞虱对缺氧反应的左右心室可塑性。我们发现，在高海拔鹿小鼠中，右心室肥大的适应不良的祖先可塑性降低。心脏转录组的分析表明，炎症信号基因表达的变化，特别是干扰素调节因子，有助于抑制右心室肥大。我们发现弱证据表明左心室质量的适应性可塑性有助于进化。我们的研究结果表明，选择抑制祖先适应不良的可塑性在适应中发挥作用。
How often phenotypic plasticity acts to promote or inhibit adaptive evolution is an ongoing debate among biologists. Recent work suggests that adaptive phenotypic plasticity promotes evolutionary divergence, though several studies have also suggested that maladaptive plasticity can potentiate adaptation. The role of phenotypic plasticity, adaptive, or maladaptive, in evolutionary divergence remains controversial. We examined the role of plasticity in evolutionary divergence between two species of Peromyscus mice that differ in native elevations. We used cardiac mass as a model phenotype, since ancestral hypoxia‐induced responses of the heart may be both adaptive and maladaptive at high‐altitude. While left ventricle growth should enhance oxygen delivery to tissues, hypertrophy of the right ventricle can lead to heart failure and death. We compared left‐ and right‐ventricle plasticity in response to hypoxia between captive‐bred P. leucopus (representing the ancestral lowland condition) and P. maniculatus from high‐altitude. We found that maladaptive ancestral plasticity in right ventricle hypertrophy is reduced in high‐altitude deer mice. Analysis of the heart transcriptome suggests that changes in expression of inflammatory signaling genes, particularly interferon regulatory factors, contribute to the suppression of right ventricle hypertrophy. We found weak evidence that adaptive plasticity of left ventricle mass contributes to evolution. Our results suggest that selection to suppress ancestral maladaptive plasticity plays a role in adaptation.