Auxiliary liver transplantation in the rat, influence of the condition of the recipient's liver on the fate of the graft.
Auxiliary liver transplantation in the rat, influence of the condition of the recipient's liver on the fate of the graft.
复制标题
大鼠辅助肝移植，受者肝脏状况对移植物命运的影响。
DOI：
10.1159/000127946
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
C. Jerusalem
中科院分区：
文献类型：
--
作者：
F. Hess;A. Willemen;C. Jerusalem
为了评估受体肝脏的功能状态对大鼠辅助肝移植命运的影响，在辅助肝移植后对受体肝脏进行了多种手术干预。所有移植物均由肝脏质量的 30% 组成，仅提供门静脉血，并提供胆汁引流。除了结扎胆管外，当接受者的肝脏被次全切除时，观察到永久性的移植物肥大。单独进行的胆管结扎对移植物重量增加的影响比肝次全切除术更明显。如果仅门脉血液偏向移植物，移植物就会萎缩。结论是，移植物的功能效率和状况直接随受体肝脏功能受损的程度（即功能肥大）而变化。目前的结果似乎并未表明门静脉血中存在特定的肝营养因子。
To evaluate the influence of the functional state of the recipient's liver on the fate of an auxiliary liver graft in rats, diverse surgical interventions were carried out on the recipient's liver following transplantation of an auxiliary liver. All grafts consisted of 30% of the liver mass, were supplied with portal blood only, and provided with bile drainage. Permanent graft hypertrophy was observed when the recipient's liver was resected subtotally, in addition to the ligation of the bile duct. Ligation of the bile duct performed separately has a more pronounced effect on the increase of the weight of the graft than subtotal hepotectomy. If only portal blood was deviated to the graft, grafts atrophied. It is concluded that the functional efficiency and condition of the graft vary directly with the degree of functional impairment of the recipient's liver, compair functional hypertrophy. The present results do not seem to indicate the presence of a specific hepatotrophic factor in portal blood.