Cardiovascular and metabolic risk profile in young people at familial risk of depression
Cardiovascular and metabolic risk profile in young people at familial risk of depression
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DOI：
10.1192/bjp.bp.113.126987
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发表时间：
2013-07-01
影响因子：
10.5
通讯作者：
Cowen, Philip J.
中科院分区：
文献类型：
--
作者：
Mannie, Zola N.;Williams, Clare;Cowen, Philip J.
背景抑郁症与多种一般疾病的风险增加有关，包括糖尿病和心血管疾病。这种关联的性质很复杂，可能涉及双向因果关系或共同的病理生理学。目的是确定没有抑郁症但家族风险增加的年轻人相对于匹配对照是否改变了代谢和血压标志物。方法我们研究了父母患有抑郁症但没有抑郁症个人史（FH+）的年轻人（n = 85）和健康对照组（n = 69）。通过空腹血样测量胰岛素、葡萄糖、血脂和高敏 C 反应蛋白 (CRP) 来评估心血管风险状况，并测量中枢和外周血压。还测量了动脉僵硬度和清醒皮质醇浓度。结果与对照组相比，FH+组表现出外周和中枢收缩压升高、动脉僵硬度增加和胰岛素敏感性降低，但在血脂、CRP或清醒皮质醇测量方面与对照组没有差异。结论我们的数据表明，家族性抑郁症风险增加的年轻人即使没有抑郁症状，也显示出成年后心血管风险状况发生改变的证据。因此，高血压和糖尿病等疾病的易感性可能先于重度抑郁症的发作，并且可能具有共同的危险因素。
BackgroundDepression is associated with increased risk of several general medical conditions, including diabetes and cardiovascular disease. The nature of the association is complex and may involve bidirectional causation or a common pathophysiology.AimsTo determine whether young people without depression but at increased familial risk have altered metabolic and blood pressure markers relative to matched controls.MethodWe studied young people (n=85), who had a parent with depression but no personal history of depressive illness (FH+) and healthy controls (n=69). Cardiovascular risk profile was assessed by a fasting blood sample to measure insulin, glucose, lipids and high-sensitivity C-reactive protein (CRP) and blood pressure was measured centrally and peripherally. Arterial stiffness and waking cortisol concentration were also measured.ResultsCompared with controls, the FH+ group demonstrated increased peripheral and central systolic blood pressure, increased arterial stiffness and diminished insulin sensitivity but they did not differ from controls in measures of lipids, CRP or waking cortisol.ConclusionsOur data suggest that young people at increased familial risk of depression show evidence of altered cardiovascular risk profile in young adulthood even in the absence of depressive symptoms. It is possible therefore that vulnerability to conditions such as hypertension and diabetes may precede the onset of major depression and may share common risk factors.