Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages
Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages
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DOI：
10.1086/491745
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发表时间：
2005-11-01
影响因子：
6.4
通讯作者：
Mege, JL
中科院分区：
文献类型：
--
作者：
Desnues, B;Lepidi, H;Mege, JL
维普莱病（WD）是由惠普尔滋养体（Tropheryma whipplei）引起的一种罕见的全身性疾病，其特征在于在诸如固有层的组织中存在泡沫状巨噬细胞，所述泡沫状巨噬细胞具有高碘酸希夫阳性包涵体。我们首次报道了WD患者肠道病变中巨噬细胞的基因表达谱。微阵列和实时聚合酶链反应显示，编码CCL 18，组织蛋白酶，清道夫受体，白细胞介素-10，和脂质代谢产物的基因在肠道病变中上调。这种转录模式对应于M2/交替激活的巨噬细胞。我们的研究结果表明，辅助性T细胞2在肠道环境中的反应可能占WD的病理生理特性。
Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff - positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.