Nerve growth factor and neuroimmune responses: basic and clinical observations.
Nerve growth factor and neuroimmune responses: basic and clinical observations.
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DOI：
10.1076/apab.109.4.354.4235
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发表时间：
2001-10-01
影响因子：
3
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Aloe, L
神经生长因子(NGF)是一种多肽，除了对外周和脑神经元的存活有影响外，还作用于免疫系统中的各种细胞。我们最近的研究表明，在炎症状态和神经免疫病理过程中，NGF的组成水平发生了显著的变化。我们还报道了自身免疫性炎症性疾病的特征是NGF的合成和利用失调。尽管这些事件所涉及的机制尚不清楚，但越来越多的证据表明，这种多肽可以在神经和皮肤组织的愈合过程中发挥重要作用，并在炎症条件下发挥作用。
Nerve growth factor (NGF) is a polypeptide that in addition to its effect on survival of peripheral and brain neuron acts also on a variety of cells localized in the immune system. We have recently shown that the constitutive levels of NGF undergo trough significant changes during inflammatory conditions and in neuroimmune pathologies. We have also reported that autoimmune inflammatory disorders are characterized by a disregulation of synthesis and utilization of NGF. Though the mechanisms implicated in these events are not yet known, there emerging evidence indicating this polypeptide can play an important role in healing processes within the nervous and cutaneous tissues and in inflammatory conditions.