Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.
Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.
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使用聚核糖磷酸（b 型流感嗜血杆菌的荚膜抗原）对人体进行免疫接种。
DOI：
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发表时间：
1972
影响因子：
15.9
通讯作者：
D. Smith
中科院分区：
文献类型：
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作者：
P. Anderson;G. Peter;R. Johnston;L. H. Wetterlow;D. Smith
在人类志愿者中，单次注射纯化的多聚核糖磷酸盐引发了可通过被动血凝和血清杀菌和调理活性检测到的针对活的B型流感嗜血杆菌的抗体。所有这三种活动都在2周后上升到最高水平，并保持至少6个月。1 μ g的剂量在几乎所有受体中引起抗体应答;然而，较高剂量的抗原产生更大的滴度增加。在6个月时给予1 μ g的加强剂量并没有进一步增加抗体滴度。在皮内注射部位经常观察到结核菌素样反应。
In human volunteers, single injections of purified polyribophosphate elicited antibodies detectable by passive hemagglutination and by serum bactericidal and opsonizing activities against viable Hemophilus influenzae, type b. All three activities rose by 2 wk to maximal levels, at which they remained for at least 6 months. Doses of 1 mug elicited antibody responses in nearly all recipients; higher doses of the antigen, however, produced larger increases in titer. Booster doses of 1 mug given at 6 months did not further increase the antibody titers. A tuberculin-like response was often observed at the site of injections given intradermally.