Nanotechnology applications in thoracic surgery.
Nanotechnology applications in thoracic surgery.
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DOI：
10.1093/ejcts/ezw002
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Sophie C. Hofferberth;M. Grinstaff;Y. Colson
中科院分区：
文献类型：
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作者：
Sophie C. Hofferberth;M. Grinstaff;Y. Colson
纳米技术是一个新兴、快速发展的领域，有可能对整个癌症治疗的护理产生重大影响。值得注意的是，最近的几项纳米技术进展显示出改善胸外科患者预后的特别前景。描述了各种纳米技术，为肺癌的检测、诊断和治疗中遇到的现有挑战提供了可能的解决方案。基于纳米技术的成像平台能够通过术中肿瘤定位、淋巴结定位和肿瘤切除准确性方面的技术进步，改善胸部恶性肿瘤患者的手术护理。此外，纳米技术有望彻底改变肺癌的辅助治疗。常见的化疗药物，如紫杉醇，多西他赛和阿霉素，正在使用各种纳米技术来改善药物递送，而基于纳米颗粒（NP）的成像技术可以监测肿瘤微环境，并促进分子靶向肺癌治疗。虽然早期基于纳米技术的递送系统显示出前景，但肺癌治疗的下一个前沿是开发能够将诊断、药物监测、肿瘤靶向和药物控释整合到各种统一平台中的“治疗诊断”多功能纳米颗粒。本文概述了在不久的将来可能在胸外科临床应用的关键现有和新兴的纳米技术平台。
Nanotechnology is an emerging, rapidly evolving field with the potential to significantly impact care across the full spectrum of cancer therapy. Of note, several recent nanotechnological advances show particular promise to improve outcomes for thoracic surgical patients. A variety of nanotechnologies are described that offer possible solutions to existing challenges encountered in the detection, diagnosis and treatment of lung cancer. Nanotechnology-based imaging platforms have the ability to improve the surgical care of patients with thoracic malignancies through technological advances in intraoperative tumour localization, lymph node mapping and accuracy of tumour resection. Moreover, nanotechnology is poised to revolutionize adjuvant lung cancer therapy. Common chemotherapeutic drugs, such as paclitaxel, docetaxel and doxorubicin, are being formulated using various nanotechnologies to improve drug delivery, whereas nanoparticle (NP)-based imaging technologies can monitor the tumour microenvironment and facilitate molecularly targeted lung cancer therapy. Although early nanotechnology-based delivery systems show promise, the next frontier in lung cancer therapy is the development of 'theranostic' multifunctional NPs capable of integrating diagnosis, drug monitoring, tumour targeting and controlled drug release into various unifying platforms. This article provides an overview of key existing and emerging nanotechnology platforms that may find clinical application in thoracic surgery in the near future.