SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
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DOI：
10.2174/187153010790827957
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
S. Kume;T. Uzu;A. Kashiwagi;D. Koya
中科院分区：
文献类型：
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作者：
S. Kume;T. Uzu;A. Kashiwagi;D. Koya
糖尿病、代谢综合征和随后的血管疾病的发病率上升现在是工业化国家的主要公共卫生问题。全世界迫切需要预防这些疾病的新治疗策略。众所周知，热量限制（CR）可以延缓从酵母到啮齿动物的生物体的衰老过程，并延缓包括糖尿病在内的许多与年龄相关的疾病的发病。因此，代谢上模拟CR的分子是年龄相关疾病的潜在新治疗靶点。沉默信息调节子2（Silent Information Regulator 2，Sir 2）是CR-mediated Life span Extension的重要参与者。还有越来越多的证据表明，哺乳动物的七种sirtuins之一，SIRT 1，参与调节细胞过程，如凋亡。SIRT 1还涉及各种组织中的葡萄糖稳态和脂质代谢，包括脂肪组织、肝脏、胰腺和骨骼肌。本文综述了目前对SIRT 1生物学功能的认识，并讨论了其作为对抗代谢和血管疾病的药理学靶点的潜力。
The rising incidence of diabetes, metabolic syndrome, and subsequent vascular diseases is now a major public health problem in industrialized countries. New therapeutic strategies to prevent these diseases are urgently needed worldwide. It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to rodents, and delay the onset of numerous age-related diseases including diabetes. Molecules that mimic CR metabolically are therefore potentially new therapeutic targets for age-related diseases. Silent information regulator 2 (Sir2) is an important player in CR-mediated life span extension. There is also increasing evidence that one of the seven mammalian sirtuins, SIRT1, is involved in regulating cellular processes such as apoptosis. SIRT1 has also been implicated in glucose homeostasis and lipid metabolism in various tissues including adipose tissues, liver, pancreas, and skeletal muscle. This review summarizes current understanding of the biological functions of SIRT1, and discusses its potential as a pharmacological target for fighting metabolic and vascular diseases.